产品
编 号：F120600
分子式：C22H20FN5O4
分子量：437.42
分子式：C22H20FN5O4
分子量：437.42
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
结构图
CAS No: 1326852-06-5
产品详情
生物活性：
STL127705 (Compound L) is a potent Ku 70/80 heterodimer protein inhibitor with an IC50 of 3.5 μM. STL127705 interferes the binding of Ku70/80 to DNA and by inhibits the activation of the DNA-PKCS kinase. STL127705 shows antiproliferative and anticancer activity. STL127705 induces apoptosis.
体外研究：
STL127705 (Compound L) (0-100 μM) inhibits binding of Ku70/80 to a DNA substrate and inhibits Ku-dependent activation of the DNA-PKCS kinase.?STL127705 (0-100 μM; 6h) decreases the expression of DNA-PKCS auto-phosphorylation in SF-767 cells.?STL127705 (0-40 μM; 6h) shows antiproliferative activity in a dose dependent manner.?TL127705 (1 μM; 48 h) significantly promotes apoptotic when combination with gemcitabine.
STL127705 (Compound L) is a potent Ku 70/80 heterodimer protein inhibitor with an IC50 of 3.5 μM. STL127705 interferes the binding of Ku70/80 to DNA and by inhibits the activation of the DNA-PKCS kinase. STL127705 shows antiproliferative and anticancer activity. STL127705 induces apoptosis.
体外研究：
STL127705 (Compound L) (0-100 μM) inhibits binding of Ku70/80 to a DNA substrate and inhibits Ku-dependent activation of the DNA-PKCS kinase.?STL127705 (0-100 μM; 6h) decreases the expression of DNA-PKCS auto-phosphorylation in SF-767 cells.?STL127705 (0-40 μM; 6h) shows antiproliferative activity in a dose dependent manner.?TL127705 (1 μM; 48 h) significantly promotes apoptotic when combination with gemcitabine.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备