产品
编 号：F120389
分子式：C16H11NO2
分子量：249.26
分子式：C16H11NO2
分子量：249.26
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
500mg
240
In-stock
5g
询价
询价
结构图
CAS No: 132-60-5
产品详情
生物活性：
Cinchophen is a potent and orally active non-steroidal anti-inflammatory agent, has analgesic and antimicrobial effects. Cinchophen can be used for the research of arthritis and some liver diseases.
体内研究：
Cinchophen (oral gavage; 25-44 mg/kg; twice daily) combines prednisolone ( 0.125-0.220 mg/kg; twice daily) for 14 days is effective in dogs with osteoarthritis and well tolerated. The combination exhibits significantly improved lameness, weight bearing, joint mobility and stiffness scores and is similar in clinical efficacy to phenylbutazone.The kinetics and efficacy of a cinchophen prednisolone combination preparation (PLT) is tested. Cinchophen administation at a dose rate of 12.5 mg/kg intravenously exhibits a volume of distribution (Vd area) of 0.13 L/kg, shows a clearance rate (Cl) of 0.15 L/h and a half-life (t1/2β) of 7.92 hours. The plasma concentration time curve (AUC0-∞) is 1187.0 μ/ml.h in dogs.Cinchophen administation (oral gavage; 12.5 mg/kg; single dose) exhibits a mean maximum plasma concentration (Cmax) of 77.75 μg/ml and the time of Cmax (tmax) is 2.76 hours. The plasma concentration time curve (AUC0-∞) is almost as large following oral as intravenous administration indicating an oral bioavailability (F) of 87.21%.
Cinchophen is a potent and orally active non-steroidal anti-inflammatory agent, has analgesic and antimicrobial effects. Cinchophen can be used for the research of arthritis and some liver diseases.
体内研究：
Cinchophen (oral gavage; 25-44 mg/kg; twice daily) combines prednisolone ( 0.125-0.220 mg/kg; twice daily) for 14 days is effective in dogs with osteoarthritis and well tolerated. The combination exhibits significantly improved lameness, weight bearing, joint mobility and stiffness scores and is similar in clinical efficacy to phenylbutazone.The kinetics and efficacy of a cinchophen prednisolone combination preparation (PLT) is tested. Cinchophen administation at a dose rate of 12.5 mg/kg intravenously exhibits a volume of distribution (Vd area) of 0.13 L/kg, shows a clearance rate (Cl) of 0.15 L/h and a half-life (t1/2β) of 7.92 hours. The plasma concentration time curve (AUC0-∞) is 1187.0 μ/ml.h in dogs.Cinchophen administation (oral gavage; 12.5 mg/kg; single dose) exhibits a mean maximum plasma concentration (Cmax) of 77.75 μg/ml and the time of Cmax (tmax) is 2.76 hours. The plasma concentration time curve (AUC0-∞) is almost as large following oral as intravenous administration indicating an oral bioavailability (F) of 87.21%.
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