产品
编 号：F120262
分子式：C17H20N4S
分子量：312.43
分子式：C17H20N4S
分子量：312.43
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
50mg
400
In-stock
100mg
560
In-stock
结构图
CAS No: 132539-06-1
产品详情
生物活性：
Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptor (Ki=19 nM). Olanzapine is an atypical antipsychotic.
体内研究：
Olanzapine (0.75、1.5 和 3 mg/kg) 评估小鼠的体重和宫周脂肪量，以及胰岛素、非酯化脂肪酸、甘油三酯和葡萄糖水平。Animal Model:Forty-two, 14, and 28 female CD-1 mice
Dosage:0.75, 1.5 and 3 mg/kg
Administration:Orally and chronically administered; 35 days
Result:Increased body weight relative to vehicle on days 20-22, and from day 32 onwards there was a straightforward increase in body weight at 3 mg/kg.No differences were found between control and mice administered olanzapine at both 1.5 and 0.75 mg/kg.
体外研究：
Olanzapine 弱结合 GABAA、苯二氮卓 (BZD) 和 β-肾上腺素能受体 (Ki>10 μM)。 Olanzapine 诱导人SH-SY5Y神经细胞系自噬。 Olanzapine (1-100 μM，血清饥饿 144 小时) 对胶质母细胞瘤细胞系和胶质瘤干细胞样细胞具有显著的抗增殖作用。 Olanzapine 还增强 Temozolomide (HY-17364) 对胶质母细胞瘤细胞系的抗肿瘤活性。 Olanzapine 诱导胶质母细胞瘤细胞系的凋亡和坏死。
Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptor (Ki=19 nM). Olanzapine is an atypical antipsychotic.
体内研究：
Olanzapine (0.75、1.5 和 3 mg/kg) 评估小鼠的体重和宫周脂肪量，以及胰岛素、非酯化脂肪酸、甘油三酯和葡萄糖水平。Animal Model:Forty-two, 14, and 28 female CD-1 mice
Dosage:0.75, 1.5 and 3 mg/kg
Administration:Orally and chronically administered; 35 days
Result:Increased body weight relative to vehicle on days 20-22, and from day 32 onwards there was a straightforward increase in body weight at 3 mg/kg.No differences were found between control and mice administered olanzapine at both 1.5 and 0.75 mg/kg.
体外研究：
Olanzapine 弱结合 GABAA、苯二氮卓 (BZD) 和 β-肾上腺素能受体 (Ki>10 μM)。 Olanzapine 诱导人SH-SY5Y神经细胞系自噬。 Olanzapine (1-100 μM，血清饥饿 144 小时) 对胶质母细胞瘤细胞系和胶质瘤干细胞样细胞具有显著的抗增殖作用。 Olanzapine 还增强 Temozolomide (HY-17364) 对胶质母细胞瘤细胞系的抗肿瘤活性。 Olanzapine 诱导胶质母细胞瘤细胞系的凋亡和坏死。
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