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编 号:F119040
分子式:C22H17N3O5
分子量:403.39
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10mM*1mL in DMSO
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50mg
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生物活性:
Azoxystrobin is an orally active, broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS) and induces cell apoptosis.

体内研究:
Azoxystrobin (0.5, 1, 10 mg/kg; Azoxystrobin 溶液混干燕片口服; 每周 2 次; 21 天) 对 E. crypticus 肠道内的细菌和真菌群落具有剂量效应,可以诱导致病菌的生长、降低有益细菌的丰度并破坏肠道微生态的稳定性。Azoxystrobin (0, 2, 25, 50 mg/kg) 能够抑制尿酶 (urease)、Invertase (HY-P2979) 和磷酸酶 (phosphatase) 的活性,改变土壤微生物群落的相对丰度。Animal Model:E. crypticus
Dosage:0.5, 1, 10 mg/kg
Administration:Solution mixed with dry oats orally; twice a week; 21 days
Result:At 10 mg/kg significantly reduced the number of larvae.Caused a dose-dependent effect on the diversity, composition, and stability of the Clostridia gut microbiota.Directly affected the gut bacterial community and indirectly affected the normalized abundance of ARGs (copies/bacterial cell).

体外研究:
Azoxystrobin (1, 5, 25 mg/L, 1 小时) 能够显著的呈剂量依赖性的降低 C. macrocarpum 孢子的萌发率,以及菌丝生长长度。Azoxystrobin 对 C. macrocarpum 具有抑制作用。Azoxystrobin (25 mg/L, 1 小时) 可以显著延迟 A. alternata 孢子的萌发,降低最终的萌发率,并且抑制菌丝生长和乳头形成。Azoxystrobin 对 A. alternata 具有明显的抑制作用。
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