产品
编 号：F118790
分子式：C14H24Cl2N2O3
分子量：339.26
分子式：C14H24Cl2N2O3
分子量：339.26
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
100
In-stock
5mg
150
In-stock
10mg
240
In-stock
50mg
480
In-stock
结构图
CAS No: 13171-25-0
产品详情
生物活性：
Trimetazidine dihydrochloride is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA). Trimetazidine dihydrochloride is an effective antianginal agent and a cytoprotective agent, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties. Trimetazidine dihydrochloride triggers autophagy. Trimetazidine dihydrochloride is also a 3-hydroxyacyl-CoA dehydrogenase (HADHA) inhibitor.
体内研究：
Trimetazidine (5-20 mg/kg; oral administration; 1 hour; Swiss albino male mice) in 10 mg/kg and 20 mg/kg doses significantly raises the seizure-threshold current in the increasing current electroshock seizure (ICES) test in the mice.Animal Model:Swiss albino male mice (24-35 g)
Dosage:5 mg/kg, 10 mg/kg and 20 mg/kg;10 mL/kg body weight
Administration:Oral administration; 1 hour
Result:In 10 mg/kg and 20 mg/kg doses significantly raised the seizure-threshold current in the ICES test.
体外研究：
Trimetazidine (1 μM-100 μM; 24 hours; HUVECs) could enhance the viability of the injured HUVECs induces by oxidation in a certain dose-dependent manner.
Trimetazidine dihydrochloride is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA). Trimetazidine dihydrochloride is an effective antianginal agent and a cytoprotective agent, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties. Trimetazidine dihydrochloride triggers autophagy. Trimetazidine dihydrochloride is also a 3-hydroxyacyl-CoA dehydrogenase (HADHA) inhibitor.
体内研究：
Trimetazidine (5-20 mg/kg; oral administration; 1 hour; Swiss albino male mice) in 10 mg/kg and 20 mg/kg doses significantly raises the seizure-threshold current in the increasing current electroshock seizure (ICES) test in the mice.Animal Model:Swiss albino male mice (24-35 g)
Dosage:5 mg/kg, 10 mg/kg and 20 mg/kg;10 mL/kg body weight
Administration:Oral administration; 1 hour
Result:In 10 mg/kg and 20 mg/kg doses significantly raised the seizure-threshold current in the ICES test.
体外研究：
Trimetazidine (1 μM-100 μM; 24 hours; HUVECs) could enhance the viability of the injured HUVECs induces by oxidation in a certain dose-dependent manner.
产品资料
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