产品
编 号:F118520
分子式:C30H48O2
分子量:440.7
产品类型
结构图
CAS No: 13159-28-9
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产品详情
生物活性:
Betulinaldehyde (Betunal) Has anti-cancer and anti-staphylococcus aureus activity. Betulinaldehyde Suppressible Akt, MAPK sum STAT3 Signal path, increase self-transfer, Suppression A549 Cellular vitality, increase and transfer. Betulinaldehyde suppresses PLCγ1/Ca2+/MMP9 signal pathway, has a key effect on vascular plasticity, and is available for cardiovascular disease (CVD) research.
体内研究:
Betulinaldehyde(50-200 mg/kg;腹腔注射;每天一次,持续 1 周)抑制裸鼠体内 A549 肿瘤异种移植物的生长。
体外研究:
Betulinaldehyde (20, 40, 80 μM; 24 h) 以浓度依赖性方式抑制 A549 细胞的集落形成能力。Betulinaldehyde (20 μM; 24 h) 抑制 Akt、MAPK 和 A549 细胞中的 STAT3。Betulinaldehyde(80 μM,160 μM;24 小时)导致颈动脉球囊损伤大鼠血管重塑,并抑制细胞内 Ca2+ 水平。