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编 号:F118415
分子式:C16H13ClN6O5
分子量:404.76
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10mM*1mL in DMSO
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5mg
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10mg
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25mg
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50mg
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生物活性:
VU591 hydrochloride is a potent, selective renal outer medullary potassium channel (ROMK or Kir1.1) inhibitor, with an IC50 of 0.24 μM. VU591 hydrochloride can be used for neurological research with HY-108585A (the equivalent of VU591 hydrochloride).

体内研究:
VU591 hydrochloride (i.c.v.; 1.842 μg) significantly decreases the immobile time in TST.Animal Model:Male ICR mice
Dosage:1.842 μg
Administration:i.c.v.; 1.842 μg
Result:Showed antidepressive effect in the tail suspension test (TST).

体外研究:
VU591 hydrochloride is a selective ROMK inhibitor and a ROMK channel pore blocker. VU591 can bind serum protein and has high metabolic stability.
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