产品
编 号：F115981
分子式：C18H16N4O2
分子量：320.35
分子式：C18H16N4O2
分子量：320.35
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 1311143-71-1
产品详情
生物活性：
JH295 is a potent, irreversible and selective NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 770 nM. JH295 inhibits cellular Nek2 via alkylation of Cys22. JH295 is inactive against the mitotic kinases, Cdk1, Aurora B or Plk1, and does not perturb bipolar spindle assembly or the spindle assembly checkpoint. JH295 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
体外研究：
JH295 (化合物 16；0.08 -20 μM；45 分钟；RPMI7951 细胞) 处理抑制细胞中的 WT Nek2，IC50 约为 1.3 μM，而它对 C22V 突变体几乎没有影响。
JH295 is a potent, irreversible and selective NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 770 nM. JH295 inhibits cellular Nek2 via alkylation of Cys22. JH295 is inactive against the mitotic kinases, Cdk1, Aurora B or Plk1, and does not perturb bipolar spindle assembly or the spindle assembly checkpoint. JH295 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
体外研究：
JH295 (化合物 16；0.08 -20 μM；45 分钟；RPMI7951 细胞) 处理抑制细胞中的 WT Nek2，IC50 约为 1.3 μM，而它对 C22V 突变体几乎没有影响。
产品资料
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