产品
编 号：F013791
分子式：C14H12ClN5O2S
分子量：349.8
分子式：C14H12ClN5O2S
分子量：349.8
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 1030203-81-6
产品详情
生物活性：
HS38 is a potent, selective, and ATP-competitive inhibitor of death-associated protein kinase 1 (DAPK1) and zipper-interacting protein kinase (ZIPK, also called DAPK3), with Kds of 300 nM and 280 nM, respectively. HS38 is also a PIM3 inhibitor with an IC50 of 200 nM. HS38 can be used for the research of smooth muscle related disorders.
体外研究：
HS38 对 DAPK2 表现出高亲和力，Kd 为 79 nM。DAPK2 与平滑肌收缩力无关。HS38 显著降低人主动脉 SM 细胞中基础和鞘氨醇 1-磷酸 (S1P) 激活状态的相对 RLC20 磷酸化。HS38 降低主动脉组织中完整小鼠主动脉产生的收缩力。HS38 降低收缩力、RLC20 磷酸化和 Ca2+ 致敏兔回肠中的 MYPT1 磷酸化。
HS38 is a potent, selective, and ATP-competitive inhibitor of death-associated protein kinase 1 (DAPK1) and zipper-interacting protein kinase (ZIPK, also called DAPK3), with Kds of 300 nM and 280 nM, respectively. HS38 is also a PIM3 inhibitor with an IC50 of 200 nM. HS38 can be used for the research of smooth muscle related disorders.
体外研究：
HS38 对 DAPK2 表现出高亲和力，Kd 为 79 nM。DAPK2 与平滑肌收缩力无关。HS38 显著降低人主动脉 SM 细胞中基础和鞘氨醇 1-磷酸 (S1P) 激活状态的相对 RLC20 磷酸化。HS38 降低主动脉组织中完整小鼠主动脉产生的收缩力。HS38 降低收缩力、RLC20 磷酸化和 Ca2+ 致敏兔回肠中的 MYPT1 磷酸化。
产品资料
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