产品
编 号：F114946
分子式：C13H9ClFNO2
分子量：265.67
分子式：C13H9ClFNO2
分子量：265.67
产品类型
规格
价格
是否有货
5mg
560
In-stock
10mg
960
In-stock
25mg
2000
In-stock
50mg
3200
In-stock
100mg
询价
询价
结构图
CAS No: 1308631-40-4
产品详情
生物活性：
NDMC101 is a potent osteoclastogenesis inhibitor and inhibits osteoclast differentiation via down-regulation of NFATc1-modulated gene expression. NDMC101 is similar to the DPP4 substrate and is a significant inhibitor of early T-cell activation via DPP4 inhibition. NDMC101can be used for study of bone disorders, such as rheumatoid arthritis, and synovial inflammation et al.
体外研究：
NDMC101 (10-15 μM) inhibits RANKL-induced osteoclast differentiation of bone marrow-derived macrophages (BMDMs) and RAW 264.7 cells. NDMC101 (15 μM) decreases RANKL-induced expression of the osteoclastogenic genes?Nfatc1,?Acp5,?Ctsk,?Oscar,?Itgb3, and?Dcstamp?in BMDMs.
NDMC101 is a potent osteoclastogenesis inhibitor and inhibits osteoclast differentiation via down-regulation of NFATc1-modulated gene expression. NDMC101 is similar to the DPP4 substrate and is a significant inhibitor of early T-cell activation via DPP4 inhibition. NDMC101can be used for study of bone disorders, such as rheumatoid arthritis, and synovial inflammation et al.
体外研究：
NDMC101 (10-15 μM) inhibits RANKL-induced osteoclast differentiation of bone marrow-derived macrophages (BMDMs) and RAW 264.7 cells. NDMC101 (15 μM) decreases RANKL-induced expression of the osteoclastogenic genes?Nfatc1,?Acp5,?Ctsk,?Oscar,?Itgb3, and?Dcstamp?in BMDMs.
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