产品
编 号：F114105
分子式：C21H27ClN2S2
分子量：407.04
分子式：C21H27ClN2S2
分子量：407.04
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
400
In-stock
500mg
640
In-stock
结构图
CAS No: 130-61-0
产品详情
生物活性：
Thioridazine hydrochloride, an orally active antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine hydrochloride is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine hydrochloride shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs).
体内研究：
Thioridazine (25 mg/kg；腹腔注射，每 3 天一次，持续 3 周) 可延长荷瘤小鼠的存活时间并减少肿瘤内多能胚胎癌 (EC) 细胞的数量。 Thioridazine (1.0-5.0 mg/kg；皮下注射) 减少口腔行为并选择性地阻止重复性头部摆动。Animal Model:Nude and Rag2KO mice were injected with iPS cells or NT2D1 cells
Dosage:25 mg/kg
Administration:I.p. every 3 days for 3 weeks
Result:Reduced the number of OCT4-expressing cells within malignant teratocarcinomas and extended the survival of tumor-bearing mice.With no effect on fertility.
体外研究：
Thioridazine (0.01-100 μM；48 h) 以浓度依赖性方式降低 NCI-N87 和 AGS 细胞的细胞活力。 Thioridazine (15 μM；24 h) 降低宫颈 (HeLa、Caski 和 C33A) 和子宫内膜 (HEC-1-A 和 KLE) 癌细胞的细胞活力。Thioridazine (1-15 μM；24-48 h) 通过线粒体凋亡途径和线粒体途径诱导胃癌细胞死亡。 Thioridazine (15 μM；24 h) 通过干扰 PI3K/Akt 通路诱导宫颈癌细胞在 G1细胞周期停滞。Thioridazine 抑制抗生素敏感和多重耐药的鲍曼不动杆菌菌株的生长。
Thioridazine hydrochloride, an orally active antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine hydrochloride is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine hydrochloride shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs).
体内研究：
Thioridazine (25 mg/kg；腹腔注射，每 3 天一次，持续 3 周) 可延长荷瘤小鼠的存活时间并减少肿瘤内多能胚胎癌 (EC) 细胞的数量。 Thioridazine (1.0-5.0 mg/kg；皮下注射) 减少口腔行为并选择性地阻止重复性头部摆动。Animal Model:Nude and Rag2KO mice were injected with iPS cells or NT2D1 cells
Dosage:25 mg/kg
Administration:I.p. every 3 days for 3 weeks
Result:Reduced the number of OCT4-expressing cells within malignant teratocarcinomas and extended the survival of tumor-bearing mice.With no effect on fertility.
体外研究：
Thioridazine (0.01-100 μM；48 h) 以浓度依赖性方式降低 NCI-N87 和 AGS 细胞的细胞活力。 Thioridazine (15 μM；24 h) 降低宫颈 (HeLa、Caski 和 C33A) 和子宫内膜 (HEC-1-A 和 KLE) 癌细胞的细胞活力。Thioridazine (1-15 μM；24-48 h) 通过线粒体凋亡途径和线粒体途径诱导胃癌细胞死亡。 Thioridazine (15 μM；24 h) 通过干扰 PI3K/Akt 通路诱导宫颈癌细胞在 G1细胞周期停滞。Thioridazine 抑制抗生素敏感和多重耐药的鲍曼不动杆菌菌株的生长。
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