产品
编 号：F113209
分子式：C25H23N3O7
分子量：477.47
分子式：C25H23N3O7
分子量：477.47
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规格
价格
是否有货
1mg
询价
询价
结构图
CAS No: 130288-24-3
产品详情
生物活性：
Duocarmycin SA is an orally active antitumor antibiotic with an IC50 of 10 pM. Duocarmycin SA is an extremely potent cytotoxic agent capable of inducing a sequence-selective alkylation of duplex DNA. Duocarmycin SA demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells treated with proton radiation in vitro.
体内研究：
Duocarmycin SA (0.143 mg/kg，腹腔注射，单次给药) 在小鼠淋巴细胞白血病 P388 移植的 CDF1 小鼠体内显示出抗肿瘤活性，使小鼠寿命显著延长 30%。Animal Model:Murine lymphocytic leukemia P388 transplanted in CDF1 mice
Dosage:0.143 mg/kg
Administration:Intraperitoneal injection (i.p.), single dose
Result:Showed a significant 30% increase in life span.
体外研究：
Duocarmycin SA (DSA) (0.1-1 nM；72 小时) 以剂量依赖性方式抑制 U-138 细胞活力，并激活凋亡和坏死途径。Duocarmycin SA (0.1 nM；72 小时) 使人胶质瘤细胞对质子辐射更加敏感。
Duocarmycin SA is an orally active antitumor antibiotic with an IC50 of 10 pM. Duocarmycin SA is an extremely potent cytotoxic agent capable of inducing a sequence-selective alkylation of duplex DNA. Duocarmycin SA demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells treated with proton radiation in vitro.
体内研究：
Duocarmycin SA (0.143 mg/kg，腹腔注射，单次给药) 在小鼠淋巴细胞白血病 P388 移植的 CDF1 小鼠体内显示出抗肿瘤活性，使小鼠寿命显著延长 30%。Animal Model:Murine lymphocytic leukemia P388 transplanted in CDF1 mice
Dosage:0.143 mg/kg
Administration:Intraperitoneal injection (i.p.), single dose
Result:Showed a significant 30% increase in life span.
体外研究：
Duocarmycin SA (DSA) (0.1-1 nM；72 小时) 以剂量依赖性方式抑制 U-138 细胞活力，并激活凋亡和坏死途径。Duocarmycin SA (0.1 nM；72 小时) 使人胶质瘤细胞对质子辐射更加敏感。
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