产品
编 号：F112968
分子式：C13H16N2O2
分子量：232.28
分子式：C13H16N2O2
分子量：232.28
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
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5mg
询价
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10mg
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25mg
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询价
结构图
CAS No: 1301211-78-8
产品详情
生物活性：
E1R is a positive allosteric modulator of sigma-1 receptors (Sig1R PAM) with cognition-enhancing activity.
体内研究：
E1R demonstrates efficacy against scopolamine-induced cholinergic dysfunction in mice. Treatment with E1R (0.1-10?mg/kg; administered i.p. 60?min before the training session) significantly improves cognitive function in a dose-related manner in mice.Animal Model:Male ICR and Balb/c mice weighed 23-25?g
Dosage:0.1, 1 and 10?mg/kg
Administration:Administered i.p. 60?min before the training session
Result:Treatment at doses of 1 and 10?mg/kg increased retention latency by 194 and 211%, respectively, compared with the control group.
体外研究：
The only target for E1R (inhibition or enhancement of radioligand binding exceeding 20%) is the sigma receptor. 10?μM E1R does not displace the radioligand, but instead increases the specific binding of a non-selective radioligand ([3H]1,3-di(2-tolyl)guanidine) for the sigma receptor by 38% in Jurkat cells.
E1R is a positive allosteric modulator of sigma-1 receptors (Sig1R PAM) with cognition-enhancing activity.
体内研究：
E1R demonstrates efficacy against scopolamine-induced cholinergic dysfunction in mice. Treatment with E1R (0.1-10?mg/kg; administered i.p. 60?min before the training session) significantly improves cognitive function in a dose-related manner in mice.Animal Model:Male ICR and Balb/c mice weighed 23-25?g
Dosage:0.1, 1 and 10?mg/kg
Administration:Administered i.p. 60?min before the training session
Result:Treatment at doses of 1 and 10?mg/kg increased retention latency by 194 and 211%, respectively, compared with the control group.
体外研究：
The only target for E1R (inhibition or enhancement of radioligand binding exceeding 20%) is the sigma receptor. 10?μM E1R does not displace the radioligand, but instead increases the specific binding of a non-selective radioligand ([3H]1,3-di(2-tolyl)guanidine) for the sigma receptor by 38% in Jurkat cells.
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