产品
编 号：F112900
分子式：C26H45NO21
分子量：707.63
分子式：C26H45NO21
分子量：707.63
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 13007-32-4
产品详情
生物活性：
Lacto-N-neotetraose (LNnT) is an endogenous metabolite. Lacto-N-neotetraose can inhibit TNF-α induced IL-8 secretion in immature epithelial cells. Lacto-N-neotetraose has anti-inflammatory avtivity, and can improve the wound closure.
体内研究：
Lacto-N-neotetraose (100 μM, intratracheal administration for 24 h) reduces the abundance of Streptococcus pneumonia in the lungs of pneumonia rabbits.Lacto-N-neotetraose (100/200 μg, Intradermal injection, at 3, 7, 14, and 21 days post-surgery) increases the wound closure rate on day 7 post-wounding.Animal Model:Rabbit model of pneumonia
Dosage:100 μM
Administration:Intratracheal administration for 24 h
Result:Decreased by ~2 logs the bacterial load in the lung at 48 h after challenge.Eliminated the extensive, edematous right middle lobe lesion evident at 48 h in control animals.
Animal Model:Mice with symmetric full-thickness wounds
Dosage:100, 200 μg
Administration:Intradermal injection, at 3, 7, 14, and 21 days post-surgery.
Result:Exhibited better healing score, follicle formation, and lower epidermal thickness index (H&E staining).
体外研究：
Lacto-N-neotetraose (5 mg/mL, 24 h) induces IL-8 secretion in T84 cells.Lacto-N-neotetraose (5 mg/mL, 24 h) reduces TNF-α induced IL-8-secretion with 38% in FHs 74 Int cells.Lacto-N-neotetraose binds TNFR1 (Tumor necrosis factor receptor 1) with a Kd value of 900 ± 660 nM.Lacto-N-neotetraose (5 mg/mL, 24 h) attenuates TNF-α induced inflammation by TNFR1 ectodomain shedding in FHs 74 Int cells.
Lacto-N-neotetraose (LNnT) is an endogenous metabolite. Lacto-N-neotetraose can inhibit TNF-α induced IL-8 secretion in immature epithelial cells. Lacto-N-neotetraose has anti-inflammatory avtivity, and can improve the wound closure.
体内研究：
Lacto-N-neotetraose (100 μM, intratracheal administration for 24 h) reduces the abundance of Streptococcus pneumonia in the lungs of pneumonia rabbits.Lacto-N-neotetraose (100/200 μg, Intradermal injection, at 3, 7, 14, and 21 days post-surgery) increases the wound closure rate on day 7 post-wounding.Animal Model:Rabbit model of pneumonia
Dosage:100 μM
Administration:Intratracheal administration for 24 h
Result:Decreased by ~2 logs the bacterial load in the lung at 48 h after challenge.Eliminated the extensive, edematous right middle lobe lesion evident at 48 h in control animals.
Animal Model:Mice with symmetric full-thickness wounds
Dosage:100, 200 μg
Administration:Intradermal injection, at 3, 7, 14, and 21 days post-surgery.
Result:Exhibited better healing score, follicle formation, and lower epidermal thickness index (H&E staining).
体外研究：
Lacto-N-neotetraose (5 mg/mL, 24 h) induces IL-8 secretion in T84 cells.Lacto-N-neotetraose (5 mg/mL, 24 h) reduces TNF-α induced IL-8-secretion with 38% in FHs 74 Int cells.Lacto-N-neotetraose binds TNFR1 (Tumor necrosis factor receptor 1) with a Kd value of 900 ± 660 nM.Lacto-N-neotetraose (5 mg/mL, 24 h) attenuates TNF-α induced inflammation by TNFR1 ectodomain shedding in FHs 74 Int cells.
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