产品
编 号：F112439
分子式：C28H35Cl3N2
分子量：505.95
分子式：C28H35Cl3N2
分子量：505.95
产品类型
规格
价格
是否有货
100mg
询价
询价
结构图
CAS No: 129-74-8
产品详情
生物活性：
Buclizine dihydrochloride is an orally active antihistamine antiallergic compound. Buclizine dihydrochloride is a potent teratogen in the rat and shows anti-tumor activity.
体内研究：
Buclizine dihydrochloride (30-200 mg/kg; tenth to fifteenth and twelfth to fifteenth days of gestation) shows potent teratogens in the rat.Animal Model:Eighty-seven mature female rats weighing 240±20 grams.
Dosage:30, 40, 60, 100, and 200 mg/kg
Administration:30-200 mg/kg; tenth to fifteenth and twelfth to fifteenth days of gestation
Result:Resulted in malformations in 100% of the young at a dose level of 60-100 mg/kg.
体外研究：
Buclizine (0.1-100 μM; 72 h) inhibits growth of MCF-7 cells.Buclizine (9.625-77 μM; 72 h) arrests the cell cycle in the G1 phase in a dose-dependent manner.Buclizine (0-75 μM; 72 h) decreases TCTP (translationally controlled tumor protein) and cell cycle regulatory proteins expression in MCF-7 cells, increases pro-apoptotic MCL-1S expression.
Buclizine dihydrochloride is an orally active antihistamine antiallergic compound. Buclizine dihydrochloride is a potent teratogen in the rat and shows anti-tumor activity.
体内研究：
Buclizine dihydrochloride (30-200 mg/kg; tenth to fifteenth and twelfth to fifteenth days of gestation) shows potent teratogens in the rat.Animal Model:Eighty-seven mature female rats weighing 240±20 grams.
Dosage:30, 40, 60, 100, and 200 mg/kg
Administration:30-200 mg/kg; tenth to fifteenth and twelfth to fifteenth days of gestation
Result:Resulted in malformations in 100% of the young at a dose level of 60-100 mg/kg.
体外研究：
Buclizine (0.1-100 μM; 72 h) inhibits growth of MCF-7 cells.Buclizine (9.625-77 μM; 72 h) arrests the cell cycle in the G1 phase in a dose-dependent manner.Buclizine (0-75 μM; 72 h) decreases TCTP (translationally controlled tumor protein) and cell cycle regulatory proteins expression in MCF-7 cells, increases pro-apoptotic MCL-1S expression.
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