产品
编 号：F112300
分子式：C69H91N15O16
分子量：1386.55
分子式：C69H91N15O16
分子量：1386.55
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CAS No: 129623-01-4
产品详情
生物活性：
GR 82334 is a potent and specific reversible tachykinin NK1 receptor antagonist. GR 82334 inhibits substance P-induced sensitization by blocking SP NK1 receptors in naked mole-rats.
体内研究：
GR 82334 (intrathecal administration; 0.1 nmol-1 nmol) excites rats unnary bladder motihty at 1 nmol but not at 0.1 nmol, and the reflex chemonociceptive is reduced by the topical application of capsaicin (4 μg/50 ul).GR 82334 (10 nM-1 μM; injected between vertebrae L4 and L5) has no effect at 10 nM in neither species, increases heat-induced foot withdrawal latency in mice at doses >100 nM, but no such increase in naked mole-rats, where doses >100 nM evoke a tendency for decreased latency.Animal Model:3-6 month-old, male C57BL/6 mice and 6-18 month-old naked mole-rats
Dosage:10 nM, 100 nM, and 1 μM
Administration:Lntrathecal injection between vertebrae L4 and L5?
Result:Increased heat-induced foot withdrawal latency in mice.
GR 82334 is a potent and specific reversible tachykinin NK1 receptor antagonist. GR 82334 inhibits substance P-induced sensitization by blocking SP NK1 receptors in naked mole-rats.
体内研究：
GR 82334 (intrathecal administration; 0.1 nmol-1 nmol) excites rats unnary bladder motihty at 1 nmol but not at 0.1 nmol, and the reflex chemonociceptive is reduced by the topical application of capsaicin (4 μg/50 ul).GR 82334 (10 nM-1 μM; injected between vertebrae L4 and L5) has no effect at 10 nM in neither species, increases heat-induced foot withdrawal latency in mice at doses >100 nM, but no such increase in naked mole-rats, where doses >100 nM evoke a tendency for decreased latency.Animal Model:3-6 month-old, male C57BL/6 mice and 6-18 month-old naked mole-rats
Dosage:10 nM, 100 nM, and 1 μM
Administration:Lntrathecal injection between vertebrae L4 and L5?
Result:Increased heat-induced foot withdrawal latency in mice.
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