产品
编 号：F111734
分子式：C13H17N5O3S
分子量：323.37
分子式：C13H17N5O3S
分子量：323.37
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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50mg
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结构图
CAS No: 1292300-75-4
产品详情
生物活性：
TASP0415914 is a potent and orally active PI3Kγ inhibitor with an IC50 of 29 nM. TASP0415914 also shows potent Akt inhibitory activities with an IC50 of 294 nM. TASP0415914 can be used for inflammatory diseases research.
体内研究：
TASP0415914 (compound 8j; 10-100 mg/kg; orally administration; twice daily; for 14 days) treatment suppressed the progression of the disease in a dose-dependent manner in a mouse collagen-induced arthritis (CIA) model.Animal Model:Collagen-primed DBA/1 mice
Dosage:10 mg/kg; 30 mg/kg; 100 mg/kg
Administration:Orally administration; twice daily; for 14 days
Result:Suppressed the progression of the disease in a dose-dependent manner.
体外研究：
TASP0415914 (compound 8j) shows high metabolic stability in rat/human liver microsomes. TASP0415914 has no CYP inhibition up to 10 μM for CYP1A2, 2C9, 2C19, 2D6 and 3A4.
TASP0415914 is a potent and orally active PI3Kγ inhibitor with an IC50 of 29 nM. TASP0415914 also shows potent Akt inhibitory activities with an IC50 of 294 nM. TASP0415914 can be used for inflammatory diseases research.
体内研究：
TASP0415914 (compound 8j; 10-100 mg/kg; orally administration; twice daily; for 14 days) treatment suppressed the progression of the disease in a dose-dependent manner in a mouse collagen-induced arthritis (CIA) model.Animal Model:Collagen-primed DBA/1 mice
Dosage:10 mg/kg; 30 mg/kg; 100 mg/kg
Administration:Orally administration; twice daily; for 14 days
Result:Suppressed the progression of the disease in a dose-dependent manner.
体外研究：
TASP0415914 (compound 8j) shows high metabolic stability in rat/human liver microsomes. TASP0415914 has no CYP inhibition up to 10 μM for CYP1A2, 2C9, 2C19, 2D6 and 3A4.
产品资料
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