产品
编 号：F111681
分子式：C19H20N2O3
分子量：324.37
分子式：C19H20N2O3
分子量：324.37
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
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10mg
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25mg
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50mg
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结构图
CAS No: 129-20-4
产品详情
生物活性：
Oxyphenbutazone is a Phenylbutazone (HY-B0230) metabolite, with anti-inflammatory effect. Oxyphenbutazone is an orally active non-selective COX inhibitor. Oxyphenbutazone selectively kills non-replicating Mycobaterium tuberculosis.
体内研究：
Oxyphenbutazone (70 mg/kg/week; p.o.; in two divided doses; for 13 weeks) exerts potential anticancer activity when co-treatment with MTX (5.0 or 2.5 mg/kg/week; i.p.).Animal Model:Wistar strain albino male rats (5-6 weeks; 150-220 g)
Dosage:70 mg/kg/week (co-treatment with MTX 5.0 or 2.5 mg/kg/week)
Administration:PO; once a week; in two divided doses; for 13 weeks
Result:Exerted potential anticancer activity in rats when co-treatment with MTX.
体外研究：
Oxyphenbutazone enhances the anticancer efficiency of Methotrexate (MTX) (HY-14519) in Hep3B cells.Oxyphenbutazone (2.5-7.5 μM; 48 hours) co-treatment with (MTX, 0.25-1.0 μM) shows potential cytotoxicity against Hep3B cells.Oxyphenbutazone exhibits reparative effects in the hepatocytes.
Oxyphenbutazone is a Phenylbutazone (HY-B0230) metabolite, with anti-inflammatory effect. Oxyphenbutazone is an orally active non-selective COX inhibitor. Oxyphenbutazone selectively kills non-replicating Mycobaterium tuberculosis.
体内研究：
Oxyphenbutazone (70 mg/kg/week; p.o.; in two divided doses; for 13 weeks) exerts potential anticancer activity when co-treatment with MTX (5.0 or 2.5 mg/kg/week; i.p.).Animal Model:Wistar strain albino male rats (5-6 weeks; 150-220 g)
Dosage:70 mg/kg/week (co-treatment with MTX 5.0 or 2.5 mg/kg/week)
Administration:PO; once a week; in two divided doses; for 13 weeks
Result:Exerted potential anticancer activity in rats when co-treatment with MTX.
体外研究：
Oxyphenbutazone enhances the anticancer efficiency of Methotrexate (MTX) (HY-14519) in Hep3B cells.Oxyphenbutazone (2.5-7.5 μM; 48 hours) co-treatment with (MTX, 0.25-1.0 μM) shows potential cytotoxicity against Hep3B cells.Oxyphenbutazone exhibits reparative effects in the hepatocytes.
产品资料
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