产品
编 号：F111444
分子式：C19H22BrNOS
分子量：392.35
分子式：C19H22BrNOS
分子量：392.35
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 1290628-31-7
产品详情
生物活性：
AZ 12216052 is a mGluR8 positive allosteric modulator, and helps mGluR8 modulate signaling inputing to retinal ganglion cells. AZ 12216052 exhibits antianxiety effect.
体内研究：
AZ 12216052 (10 mg/kg; i.p.; 2 h prior to testing) reduces measures of anxiety, without affecting the velocity of the mice.AZ12216052 (10 mg/kg; i.p.; single dose) exhibits remaining anxiolytic effects, might involve mGluR4 in mGluR8?/? mice, as the mGluR4 PAM (Positive Allosteric Modulator) VU 0155041 also reduces measures of anxiety in wild-type mice.Animal Model:WT and Apolipoprotein E-deficient (Apoe?/?) mice (C57BL/6J, 2-month-old) in the elevated zero maze
Dosage:10 mg/kg
Administration:Intraperitoneal injection; singel dose, 2 h prior to testing
Result:Reduced measures of anxiety in the elevated zero maze without affecting the velocity of the mice.Reduced the acoustic startle response.
体外研究：
mGluR8 may modulates the synaptic inputs to retinal ganglion cells.AZ 12216052 (10 μM) enhances the peak excitatory currents of ON-, OFF- currents in ON-OFF-ganglion cells, with a dependent way on the intensity of the light stimuli.AZ 12216052 shows impact of cell differentiation and (0.01-1 μM; 24-48 h) reduces Dox-induced human neuroblastoma SH-SY5Y cell damage partially.AZ 12216052 stimulates proliferation and attenuates staurosporine (St)- and doxorubicin (Dox)-induced toxicity in UN-SH-SY5Y cells.AZ12216052 (10 μM) enhances glutamate activity of human mGluR8b receptor expressed in GHEK cells.
AZ 12216052 is a mGluR8 positive allosteric modulator, and helps mGluR8 modulate signaling inputing to retinal ganglion cells. AZ 12216052 exhibits antianxiety effect.
体内研究：
AZ 12216052 (10 mg/kg; i.p.; 2 h prior to testing) reduces measures of anxiety, without affecting the velocity of the mice.AZ12216052 (10 mg/kg; i.p.; single dose) exhibits remaining anxiolytic effects, might involve mGluR4 in mGluR8?/? mice, as the mGluR4 PAM (Positive Allosteric Modulator) VU 0155041 also reduces measures of anxiety in wild-type mice.Animal Model:WT and Apolipoprotein E-deficient (Apoe?/?) mice (C57BL/6J, 2-month-old) in the elevated zero maze
Dosage:10 mg/kg
Administration:Intraperitoneal injection; singel dose, 2 h prior to testing
Result:Reduced measures of anxiety in the elevated zero maze without affecting the velocity of the mice.Reduced the acoustic startle response.
体外研究：
mGluR8 may modulates the synaptic inputs to retinal ganglion cells.AZ 12216052 (10 μM) enhances the peak excitatory currents of ON-, OFF- currents in ON-OFF-ganglion cells, with a dependent way on the intensity of the light stimuli.AZ 12216052 shows impact of cell differentiation and (0.01-1 μM; 24-48 h) reduces Dox-induced human neuroblastoma SH-SY5Y cell damage partially.AZ 12216052 stimulates proliferation and attenuates staurosporine (St)- and doxorubicin (Dox)-induced toxicity in UN-SH-SY5Y cells.AZ12216052 (10 μM) enhances glutamate activity of human mGluR8b receptor expressed in GHEK cells.
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