产品
编 号：F109812
分子式：C6H7NO2
分子量：125.13
分子式：C6H7NO2
分子量：125.13
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
250
In-stock
10mg
380
In-stock
50mg
979
In-stock
100mg
1471
In-stock
结构图
CAS No: 128-53-0
产品详情
生物活性：
N-Ethylmaleimide (NEM) derives from maleic acid, it can alkylates free sulfhydryl. N-Ethylmaleimide is an irreversible cysteine protease inhibitor. N-ethylmaleimide specific inhibits phosphate transport in mitochondria. N-Ethylmaleimide inhibits prolyl endopeptidase with an IC50 value of 6.3 μM. N-Ethylmaleimide can be used to modify cysteine residues in proteins and peptides.
体内研究：
N-Ethylmaleimide (10 mg/kg; i.h.) promotes the prevalence situation of mice with acute gastric ulcers.Animal Model:Male Wistar rats with acute gastric ulcers induced by absolute ethanol injection
Dosage:10 mg/kg
Administration:Subcutaneous injection; 10 mg/kg once
Result:Increased the lesion area of acute gastric ulcers and attenuated the gastroprotective effect of PAG in rats.
体外研究：
N-Ethylmaleimide (20 μM;30 min) inhibits Akt Ser-473, Akt Thr-308 , p70S6K, ribosomal protein S6, 4E-BP1, eIF4E, BAD and FKHR-L1 phosphorylation.N-Ethylmaleimide (20 μM;30 min) affects conversion of pro-caspase-3 in vascular smooth muscle cells.N-Ethylmaleimide (20 μM;6 h) promotes vascular smooth muscle cells apoptosis.N-Ethylmaleimide (20 μM;30 min) affects PP2A activity and ROS production in vascular smooth muscle cells.
N-Ethylmaleimide (NEM) derives from maleic acid, it can alkylates free sulfhydryl. N-Ethylmaleimide is an irreversible cysteine protease inhibitor. N-ethylmaleimide specific inhibits phosphate transport in mitochondria. N-Ethylmaleimide inhibits prolyl endopeptidase with an IC50 value of 6.3 μM. N-Ethylmaleimide can be used to modify cysteine residues in proteins and peptides.
体内研究：
N-Ethylmaleimide (10 mg/kg; i.h.) promotes the prevalence situation of mice with acute gastric ulcers.Animal Model:Male Wistar rats with acute gastric ulcers induced by absolute ethanol injection
Dosage:10 mg/kg
Administration:Subcutaneous injection; 10 mg/kg once
Result:Increased the lesion area of acute gastric ulcers and attenuated the gastroprotective effect of PAG in rats.
体外研究：
N-Ethylmaleimide (20 μM;30 min) inhibits Akt Ser-473, Akt Thr-308 , p70S6K, ribosomal protein S6, 4E-BP1, eIF4E, BAD and FKHR-L1 phosphorylation.N-Ethylmaleimide (20 μM;30 min) affects conversion of pro-caspase-3 in vascular smooth muscle cells.N-Ethylmaleimide (20 μM;6 h) promotes vascular smooth muscle cells apoptosis.N-Ethylmaleimide (20 μM;30 min) affects PP2A activity and ROS production in vascular smooth muscle cells.
产品资料
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