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编 号:F109695
分子式:C18H23NO4
分子量:317.38
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生物活性:
Arbutamine is a short-acting, potent and nonselective β-adrenoceptor agonist. Arbutamine stimulates cardiac β1-, tracheal β2-, and adiopocyte β3- adrenergic receptors. Arbutamine provides cardiac stress increases heart rate, cardiac contractility, and systolic blood pressure. Arbutamine can be used for cardiac stress agent .

体内研究:
Arbutamine (i.v.; 5, 10, 50, 100, and 250 ng/kg/min) increases mean heart rate, peak positive left ventricular pressure and its first time-derivative, and normal-zone myocardial thickening in 8 open-chest dogs (mean weight, 26.91 kg).

体外研究:
Arbutamine (0.1-100 nM) increases heart contractile force and pD2 value of 8.45. Arbutamine has the affinity constants (KA) value of 7.32 for cardiac β1-adrenergic receptors.
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