产品
编 号:F108379
分子式:C18H13ClFNO3S
分子量:377.82
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10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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50mg
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生物活性:
CU-CPT 4a (TLR3-IN-1) is a potent, highly selective TLR3 signaling inhibitor. CU-CPT 4a represses the expression of downstream signaling pathways mediated by the TLR3/dsRNA complex, including TNF-α and IL-1β.

体外研究:
CU-CPT 4a shows dose-dependent inhibitory effects blocking Poly (I:C)-induced TLR3 activation with an IC50 of 3.44 μM.CU-CPT 4a competes with dsRNA for binding to TLR3 with a Ki of 2.96 μM.
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