产品
编 号：F107181
分子式：C40H56O2
分子量：568.87
分子式：C40H56O2
分子量：568.87
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
400
In-stock
10mg
640
In-stock
20mg
1120
In-stock
结构图
CAS No: 127-40-2
产品详情
生物活性：
Lutein (Xanthophyll) is a carotenoid with reported anti-inflammatory properties. A large body of evidence shows that lutein has several beneficial effects, especially on eye health. Lutein exerts its biological activities, including anti-inflammation, anti-oxidase and anti-apoptosis, through effects on reactive oxygen species (ROS). Lutein is able to arrive in the brain and shows antidepressant-like and neuroprotective effects. Lutein is orally active.
体内研究：
Lutein (40-160 mg/kg; in diet for 5 weeks) protects against severe traumatic brain injury through anti-inflammation and anti-oxidative effects via ICAM-1/Nrf-2 in rats.Lutein (0.1-10 mg/kg; p.o.; once or daily for 7 and 21 days) prevents Corticosterone (HY-B1618)-induced depressive-like behavior in mice with the involvement of antioxidant and neuroprotective activities.Animal Model:Sprague-Dawley rats, severe traumatic brain injury (STBI) model
Dosage:40, 80 and 160 mg/kg
Administration:In diet for 5 weeks
Result:Suppressed, interleukin (IL)-1β, IL-6 and monocyte chemoattractant protein-1 expression, reduced serum ROS levels, and reduced superoxide dismutase and glutathione peroxidase activities. Effectively downregulated the expression of NF-κB p65 and cyclooxygenase-2, intercellular adhesion molecule (ICAM)-1 protein, and upregulated nuclear factor erythroid 2 like 2 (Nrf-2) and endothelin-1 protein levels.
Animal Model:Male Swiss mice, chronic Corticosterone (HY-B1618) model of depression
Dosage:0.1, 1 and 10 mg/kg
Administration:Oral administration, once or daily for 7 and 21 days
Result:Decreased immobility time at the dose 10 mg/kg. Counteracted the behavioral changes displayed by Corticosterone (HY-B1618) showing antidepressant-like effect. Presented antioxidant effect in the hippocampus, prefrontal cortex and plasma of mice, and exhibited a capability to protect hippocampal and prefrontal cortex slices against glutamatergic toxicity.
体外研究：
Lutein (100 or 200 μM) protects against A2-PE (a bis-retinoid compound that is the immediate precursor of the lipofuscin fluorophore A2E) photooxidation and reduces A2E photooxidation.
Lutein (Xanthophyll) is a carotenoid with reported anti-inflammatory properties. A large body of evidence shows that lutein has several beneficial effects, especially on eye health. Lutein exerts its biological activities, including anti-inflammation, anti-oxidase and anti-apoptosis, through effects on reactive oxygen species (ROS). Lutein is able to arrive in the brain and shows antidepressant-like and neuroprotective effects. Lutein is orally active.
体内研究：
Lutein (40-160 mg/kg; in diet for 5 weeks) protects against severe traumatic brain injury through anti-inflammation and anti-oxidative effects via ICAM-1/Nrf-2 in rats.Lutein (0.1-10 mg/kg; p.o.; once or daily for 7 and 21 days) prevents Corticosterone (HY-B1618)-induced depressive-like behavior in mice with the involvement of antioxidant and neuroprotective activities.Animal Model:Sprague-Dawley rats, severe traumatic brain injury (STBI) model
Dosage:40, 80 and 160 mg/kg
Administration:In diet for 5 weeks
Result:Suppressed, interleukin (IL)-1β, IL-6 and monocyte chemoattractant protein-1 expression, reduced serum ROS levels, and reduced superoxide dismutase and glutathione peroxidase activities. Effectively downregulated the expression of NF-κB p65 and cyclooxygenase-2, intercellular adhesion molecule (ICAM)-1 protein, and upregulated nuclear factor erythroid 2 like 2 (Nrf-2) and endothelin-1 protein levels.
Animal Model:Male Swiss mice, chronic Corticosterone (HY-B1618) model of depression
Dosage:0.1, 1 and 10 mg/kg
Administration:Oral administration, once or daily for 7 and 21 days
Result:Decreased immobility time at the dose 10 mg/kg. Counteracted the behavioral changes displayed by Corticosterone (HY-B1618) showing antidepressant-like effect. Presented antioxidant effect in the hippocampus, prefrontal cortex and plasma of mice, and exhibited a capability to protect hippocampal and prefrontal cortex slices against glutamatergic toxicity.
体外研究：
Lutein (100 or 200 μM) protects against A2-PE (a bis-retinoid compound that is the immediate precursor of the lipofuscin fluorophore A2E) photooxidation and reduces A2E photooxidation.
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