产品
编 号：F106554
分子式：C4H9NO
分子量：87.12
分子式：C4H9NO
分子量：87.12
产品类型
规格
价格
是否有货
100mL
440
In-stock
结构图
CAS No: 127-19-5
产品详情
生物活性：
N,N-Dimethylacetamide (DMAc) is an organic solvent with blood-brain transmissibility and an FDA-approved drug excipient. N, N-dimethylacetamide exerts anti-inflammatory activity by inhibiting the NF-κB signaling pathway. N, N-dimethylacetamide can be used in studies of weight gain caused by a high-fat diet and neuroinflammation in Alzheimer's disease.
体内研究：
N,N-Dimethylacetamide (0.2, 0.39, 0.78, 1.56, 3.1 mg/kg, 腹腔注射) 可预防内毒素诱导的 C57BL/6 胚胎日 (E) 15.5 小鼠的早产，并以剂量依赖的方式使其幼崽免于自然流产。 N,N-Dimethylacetamide (2.1 g/kg/day, 腹腔注射) 可减弱 DSS 诱导的结肠炎的临床和组织学特征。Animal Model:LPS-Triggered PTB and Spontaneous Abortions mice
Dosage:0.2, 0.39, 0.78, 1.56, 3,1 mg/kg
Administration:i.p. Single dose
Result:Attenuated the excessive endotoxin-triggered proinflammatory response that leads to preterm delivery.
Animal Model:DSS-induced colitis in C57Bl/6 mice
Dosage:2.1 g/kg
Administration:i.p. once a day for four days
Result:Attenuated inflammation, crypt injury and ulceration.
体外研究：
N,N-Dimethylacetamide (10-1000 μM, 24 h) 在 RAW 264.7 细胞中抑制巨噬细胞的杀菌活性。N,N-Dimethylacetamide (0.1-10 mM, 2 h) 在小胶质细胞系 SIM-A9 和 HMC3 中可抑制 a β 诱导的炎症。
N,N-Dimethylacetamide (DMAc) is an organic solvent with blood-brain transmissibility and an FDA-approved drug excipient. N, N-dimethylacetamide exerts anti-inflammatory activity by inhibiting the NF-κB signaling pathway. N, N-dimethylacetamide can be used in studies of weight gain caused by a high-fat diet and neuroinflammation in Alzheimer's disease.
体内研究：
N,N-Dimethylacetamide (0.2, 0.39, 0.78, 1.56, 3.1 mg/kg, 腹腔注射) 可预防内毒素诱导的 C57BL/6 胚胎日 (E) 15.5 小鼠的早产，并以剂量依赖的方式使其幼崽免于自然流产。 N,N-Dimethylacetamide (2.1 g/kg/day, 腹腔注射) 可减弱 DSS 诱导的结肠炎的临床和组织学特征。Animal Model:LPS-Triggered PTB and Spontaneous Abortions mice
Dosage:0.2, 0.39, 0.78, 1.56, 3,1 mg/kg
Administration:i.p. Single dose
Result:Attenuated the excessive endotoxin-triggered proinflammatory response that leads to preterm delivery.
Animal Model:DSS-induced colitis in C57Bl/6 mice
Dosage:2.1 g/kg
Administration:i.p. once a day for four days
Result:Attenuated inflammation, crypt injury and ulceration.
体外研究：
N,N-Dimethylacetamide (10-1000 μM, 24 h) 在 RAW 264.7 细胞中抑制巨噬细胞的杀菌活性。N,N-Dimethylacetamide (0.1-10 mM, 2 h) 在小胶质细胞系 SIM-A9 和 HMC3 中可抑制 a β 诱导的炎症。
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