产品
编 号：F104895
分子式：C18H24N8O3S
分子量：432.5
分子式：C18H24N8O3S
分子量：432.5
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CAS No: 1268273-23-9
产品详情
生物活性：
YK5 is a potent and selective Hsp70 inhibitor. YK5 selectively and tightly binds to the cytosolic Hsp70s in cancer cells. YK5 has biological activity partly by interfering with the formation of active oncogenic Hsp70/Hsp90/client protein complexes.
体外研究：
YK5 shows selectively and tightly binds to the cytosolic Hsp70s.YK5 (0.5, 1, 5 μM; 72 h) degrades the expression of Hsp90/Hsp70-onco-client proteins and also leads to the inhibition of cell proliferation in SKBr3 cells.YK5 (0.5, 1, 5 μM; 24 h) induces the degradation of HER2, Raf-1, Akt kinases, and also induces apoptosis in SKBr3 cells.
YK5 is a potent and selective Hsp70 inhibitor. YK5 selectively and tightly binds to the cytosolic Hsp70s in cancer cells. YK5 has biological activity partly by interfering with the formation of active oncogenic Hsp70/Hsp90/client protein complexes.
体外研究：
YK5 shows selectively and tightly binds to the cytosolic Hsp70s.YK5 (0.5, 1, 5 μM; 72 h) degrades the expression of Hsp90/Hsp70-onco-client proteins and also leads to the inhibition of cell proliferation in SKBr3 cells.YK5 (0.5, 1, 5 μM; 24 h) induces the degradation of HER2, Raf-1, Akt kinases, and also induces apoptosis in SKBr3 cells.
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