产品
编 号：F104121
分子式：C31H45F2N5O5
分子量：605.72
分子式：C31H45F2N5O5
分子量：605.72
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规格
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CAS No: 1266227-69-3
产品详情
生物活性：
T-3256336 is a potent and orally active cIAP1 and XIAP inhibitor with IC50s of 1.3, 200 nM, respectively. T-3256336 shows anti-tumor activity.
体内研究：
T-3256336 (compound 45) (30, 100 mg/kg; p.o.) 增加 caspase-3/7 活性并在小鼠中显示抗肿瘤活性。Animal Model:Female BALB/cAJcl mice (MDA-MB-231-Luc xenograft)
Dosage:30, 100 mg/kg
Administration:P.o.
Result:Stimulated caspase-3/7 activity in a dose-dependent manner, induced tumor regression in a dose-dependent manner with a percent tumor growth inhibition (T/C) of 53% and 62% at 30 mg/kg and 100 mg/kg, respectively.
T-3256336 is a potent and orally active cIAP1 and XIAP inhibitor with IC50s of 1.3, 200 nM, respectively. T-3256336 shows anti-tumor activity.
体内研究：
T-3256336 (compound 45) (30, 100 mg/kg; p.o.) 增加 caspase-3/7 活性并在小鼠中显示抗肿瘤活性。Animal Model:Female BALB/cAJcl mice (MDA-MB-231-Luc xenograft)
Dosage:30, 100 mg/kg
Administration:P.o.
Result:Stimulated caspase-3/7 activity in a dose-dependent manner, induced tumor regression in a dose-dependent manner with a percent tumor growth inhibition (T/C) of 53% and 62% at 30 mg/kg and 100 mg/kg, respectively.
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