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编 号：F103945
分子式：C71H81N19O18S5
分子量：1648.84
分子式：C71H81N19O18S5
分子量：1648.84
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CAS No: 12656-09-6
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生物活性：
Siomycin A is a thiopeptide antibiotic and is a Forkhead box M1(FOXM1) selective inhibitor without affecting other members of the Forkhead box family. Siomycin A has anti-tumor and promotes apoptosis.
体内研究：
Siomycin A (1 μM; subcutaneous injection; for 4 weeks; male Balb/c nude mice) pretreatment decreases tumour growth in an in vivo mouse model.Animal Model:Four- to five-week old male Balb/c nude mice withIOMM-LEE cells
Dosage:1 μM-pretreated IOMM-Lee cells
Administration:Subcutaneous injection; for 4 weeks
Result:Decreased tumour growth in an in vivo mouse model.
体外研究：
Siomycin A (0-10 μM; 24-72 hours; K562, MCF7 and MiaPaCa-2 cells) treatment markedly reduces cell viability in a dose-dependent and a time-dependent association in K562, MCF7 and MiaPaCa-2 cells. Among the three cell lines, the IC50 of the human leukemia K562 cells is the lowest at 6.25 μM at 24 h, while that for the human pancreatic cancer MiaPaCa-2 cells is 6.38 μM. However, the IC50 of the human pancreatic cancer MiaPaCa-2 cells at 48 and 72 h are the lowest of the three cell lines, which are 0.76 and 0.54 μM, respectively.Siomycin A (0-10 μM; MiaPaCa-2 cells) treatment has potent proapoptotic effect in MiaPaCa-2 cells.Siomycin A (0-10 μM; 24 hours; MiaPaCa-2 cells) treatment significantly reduces the expression levels of MMP-2, MMP-9 and α-tubulin protein in the MiaPaCa-2 cells.
Siomycin A is a thiopeptide antibiotic and is a Forkhead box M1(FOXM1) selective inhibitor without affecting other members of the Forkhead box family. Siomycin A has anti-tumor and promotes apoptosis.
体内研究：
Siomycin A (1 μM; subcutaneous injection; for 4 weeks; male Balb/c nude mice) pretreatment decreases tumour growth in an in vivo mouse model.Animal Model:Four- to five-week old male Balb/c nude mice withIOMM-LEE cells
Dosage:1 μM-pretreated IOMM-Lee cells
Administration:Subcutaneous injection; for 4 weeks
Result:Decreased tumour growth in an in vivo mouse model.
体外研究：
Siomycin A (0-10 μM; 24-72 hours; K562, MCF7 and MiaPaCa-2 cells) treatment markedly reduces cell viability in a dose-dependent and a time-dependent association in K562, MCF7 and MiaPaCa-2 cells. Among the three cell lines, the IC50 of the human leukemia K562 cells is the lowest at 6.25 μM at 24 h, while that for the human pancreatic cancer MiaPaCa-2 cells is 6.38 μM. However, the IC50 of the human pancreatic cancer MiaPaCa-2 cells at 48 and 72 h are the lowest of the three cell lines, which are 0.76 and 0.54 μM, respectively.Siomycin A (0-10 μM; MiaPaCa-2 cells) treatment has potent proapoptotic effect in MiaPaCa-2 cells.Siomycin A (0-10 μM; 24 hours; MiaPaCa-2 cells) treatment significantly reduces the expression levels of MMP-2, MMP-9 and α-tubulin protein in the MiaPaCa-2 cells.
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