产品
编 号：F103562
分子式：C23H47N5O18S
分子量：713.71
分子式：C23H47N5O18S
分子量：713.71
产品类型
规格
价格
是否有货
500mg
320
In-stock
1g
400
In-stock
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CAS No: 1263-89-4
产品详情
生物活性：
Paromomycin (Aminosidine) sulfate, a neomycin (HY-B0470) derivative, is a broad spectrum aminoglycoside antibiotic with amebicidal and bactericidal effects. Paromomycin sulfate prematures termination of translation of mRNA and inhibits protein synthesis?by specifically binds to the RNA oligonucleotide at the A site of bacterial 30S ribosomes. Paromomycin sulfate can be used for the research of bacterial and parasitic infections.
体内研究：
Paromomycin sulfate (oral gavage; 50 mg/kg-200 mg/kg; once daily; for five consecutive days two weeks post infection) reduces the number of oocyst per gram of feces and intestine. It shows minimal focal inflammation in only 20% of the sections at 50 mg/kg from the intestines of mice infected with C. parvum and only 10% of focal inflammation at 200 mg/kg.Animal Model:Male Swiss albino mice
Dosage:50 mg/kg-200 mg/kg
Administration:Oral gavage; 50 mg/kg-200 mg/kg; once daily; for five consecutive days two weeks post infection
Result:Was against cryptosporidiosis in vivo.
体外研究：
Paromomycin sulfate (500 μg/ml) reduces intracellular parasitic forms by 97.2% compared to control in Caco-2 cells and reduces the percentage of intracellular C. parvum forms by 99.5% in HCT-8 cells.
Paromomycin (Aminosidine) sulfate, a neomycin (HY-B0470) derivative, is a broad spectrum aminoglycoside antibiotic with amebicidal and bactericidal effects. Paromomycin sulfate prematures termination of translation of mRNA and inhibits protein synthesis?by specifically binds to the RNA oligonucleotide at the A site of bacterial 30S ribosomes. Paromomycin sulfate can be used for the research of bacterial and parasitic infections.
体内研究：
Paromomycin sulfate (oral gavage; 50 mg/kg-200 mg/kg; once daily; for five consecutive days two weeks post infection) reduces the number of oocyst per gram of feces and intestine. It shows minimal focal inflammation in only 20% of the sections at 50 mg/kg from the intestines of mice infected with C. parvum and only 10% of focal inflammation at 200 mg/kg.Animal Model:Male Swiss albino mice
Dosage:50 mg/kg-200 mg/kg
Administration:Oral gavage; 50 mg/kg-200 mg/kg; once daily; for five consecutive days two weeks post infection
Result:Was against cryptosporidiosis in vivo.
体外研究：
Paromomycin sulfate (500 μg/ml) reduces intracellular parasitic forms by 97.2% compared to control in Caco-2 cells and reduces the percentage of intracellular C. parvum forms by 99.5% in HCT-8 cells.
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