产品
编 号：F102878
分子式：C18H26N6O
分子量：342.44
分子式：C18H26N6O
分子量：342.44
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CAS No: 1262832-74-5
产品详情
生物活性：
PF-00956980 is a reversible pan-JAK inhibitor with IC50 values of 2.2, 23.1 and 59.9 μM for JAK1, JAK2 and JAK3, respectively. PF-00956980 can be used in the research of lung and skin inflammatory diseases.
体内研究：
The pharmacokinetic parameters of PF-00956980(compound 2) in rat or dog SpesiesDose (mg/kg)Cl (mL/min/Kg)Clunbound (mL/min/Kg) Vss (L/Kg) Terminal T1/2 (h)Oral Bioavailability Rat i.v.0.548>48,0000.82.1-Rat p.o.1----18,0001.02.0-
PF-00956980 is a reversible pan-JAK inhibitor with IC50 values of 2.2, 23.1 and 59.9 μM for JAK1, JAK2 and JAK3, respectively. PF-00956980 can be used in the research of lung and skin inflammatory diseases.
体内研究：
The pharmacokinetic parameters of PF-00956980(compound 2) in rat or dog SpesiesDose (mg/kg)Cl (mL/min/Kg)Clunbound (mL/min/Kg) Vss (L/Kg) Terminal T1/2 (h)Oral Bioavailability Rat i.v.0.548>48,0000.82.1-Rat p.o.1----18,0001.02.0-
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