产品
编 号:F098764
分子式:C22H21N3O4
分子量:391.42
产品类型
结构图
CAS No: 1258494-60-8
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产品详情
生物活性:
TH1338 (compound 3b), an orally active camptothecin derivative and a potent chemotherapeutic agent for cancer, demonstrates excellent cytotoxic potency against human tumor cell lines in vitro. TH1338 (compound 3b) possesses significant brain penetration, favorable efflux pump properties, and hematological toxicity profile.
体外研究:
TH1338 (compound 3b) demonstrates significant brain penetration when dosed orally in mice.TH1338 (compound 3b) exhibits potent anti-tumor activity in H460 (NSCLC) human tumor xenograft model.