产品
编 号：F098691
分子式：C17H11ClF2N4O2
分子量：376.74
分子式：C17H11ClF2N4O2
分子量：376.74
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价格
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CAS No: 1258294-34-6
产品详情
生物活性：
TCJL37 is a potent, selective, and orally bioavailable TYK2 inhibitor with a Ki of 1.6 nM. TCJL37 can be used for the research of inflammatory bowel diseases (IBD).
体内研究：
TCJL37 exhibits excellent oral exposure in CD-1 mice following oral administration (100 mg/kg). TCJL37 exhibits low clearance (1.0 mL/min/kg) in rat.
体外研究：
In cell-based assays, TCJL37 (Compound 37) shows IL-12 pSTAT4 EC50 of 224 nM. TCJL37 shows EC50s of 168 nM and 737 nMIn human peripheral blood mononuclear cells (PBMC) and human whole blood assay, respectively.
TCJL37 is a potent, selective, and orally bioavailable TYK2 inhibitor with a Ki of 1.6 nM. TCJL37 can be used for the research of inflammatory bowel diseases (IBD).
体内研究：
TCJL37 exhibits excellent oral exposure in CD-1 mice following oral administration (100 mg/kg). TCJL37 exhibits low clearance (1.0 mL/min/kg) in rat.
体外研究：
In cell-based assays, TCJL37 (Compound 37) shows IL-12 pSTAT4 EC50 of 224 nM. TCJL37 shows EC50s of 168 nM and 737 nMIn human peripheral blood mononuclear cells (PBMC) and human whole blood assay, respectively.
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