产品
编 号：F098184
分子式：C15H11ClN4O3
分子量：330.73
分子式：C15H11ClN4O3
分子量：330.73
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CAS No: 1257256-44-2
产品详情
生物活性：
TC-G 24 (Compound 24) is a potent, selective glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 of 17.1 nM. TC-G 24 can cross the BBB and can be used for studying many diseases such as type 2 diabetes mellitus, stroke, Alzheimer, and other related diseases.
体内研究：
TC-G 24 (Compound 24) (0-15 mg/kg; i.p.; once) significantly raises liver glycogen content in a dose-dependent manner without obvious toxicity and can cross the BBB.Animal Model:Six-week-old male C57BL/6N mice with weights averaging 22 g
Dosage:1, 5, and 15 mg/kg
Administration:Intraperitoneal injection, once
Result:Significantly raised liver glycogen content in a dose-dependent manner without obvious toxicity. Was detected in the brain at concentrations higher than in plasma for all three tested doses (38 ± 6, 113 ± 54 and 286 ± 58 ng/g brain tissue at 1, 5 and 15 mg/kg, respectively).
体外研究：
TC-G 24 (Compound 24) binds to the ATP binding site of GSK-3β.TC-G 24 (1 μM, 4 h) blocks the FBW7α-mediated degradation of TPP1 in human embryonic kidney (HEK) 293T cells.
TC-G 24 (Compound 24) is a potent, selective glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 of 17.1 nM. TC-G 24 can cross the BBB and can be used for studying many diseases such as type 2 diabetes mellitus, stroke, Alzheimer, and other related diseases.
体内研究：
TC-G 24 (Compound 24) (0-15 mg/kg; i.p.; once) significantly raises liver glycogen content in a dose-dependent manner without obvious toxicity and can cross the BBB.Animal Model:Six-week-old male C57BL/6N mice with weights averaging 22 g
Dosage:1, 5, and 15 mg/kg
Administration:Intraperitoneal injection, once
Result:Significantly raised liver glycogen content in a dose-dependent manner without obvious toxicity. Was detected in the brain at concentrations higher than in plasma for all three tested doses (38 ± 6, 113 ± 54 and 286 ± 58 ng/g brain tissue at 1, 5 and 15 mg/kg, respectively).
体外研究：
TC-G 24 (Compound 24) binds to the ATP binding site of GSK-3β.TC-G 24 (1 μM, 4 h) blocks the FBW7α-mediated degradation of TPP1 in human embryonic kidney (HEK) 293T cells.
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