产品
编 号：F098055
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规格
价格
是否有货
1mg
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5mg
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10mg
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结构图
CAS No: 1256937-27-5
产品详情
生物活性：
Evolocumab (AMG 145) is a human monoclonal antibody that inhibits PCSK9. Evolocumab is used in the study of hypercholesterolemia and atherosclerotic cardiovascular disease. Evolocumab binds to circulating PCSK9 protein and inhibits its binding to LDLR. Evolocumab has antioxidant and cytoprotective activities against H2O2-induced oxidative damage to endothelial cells. Evolocumab may also negatively regulate activation of the TLR-4/NF-κB signaling pathway to prevent inflammation.
体外研究：
Evolocumab (5-100 μg/mL) 可显著阻止 H2O2 对人脐静脉内皮细胞 (HUVEC) 的细胞毒性。Evolocumab (100 μg/mL) 可减少大鼠视网膜 Müller 细胞 (RMC) 受刺激而增加的炎症因子的表达和分泌。
Evolocumab (AMG 145) is a human monoclonal antibody that inhibits PCSK9. Evolocumab is used in the study of hypercholesterolemia and atherosclerotic cardiovascular disease. Evolocumab binds to circulating PCSK9 protein and inhibits its binding to LDLR. Evolocumab has antioxidant and cytoprotective activities against H2O2-induced oxidative damage to endothelial cells. Evolocumab may also negatively regulate activation of the TLR-4/NF-κB signaling pathway to prevent inflammation.
体外研究：
Evolocumab (5-100 μg/mL) 可显著阻止 H2O2 对人脐静脉内皮细胞 (HUVEC) 的细胞毒性。Evolocumab (100 μg/mL) 可减少大鼠视网膜 Müller 细胞 (RMC) 受刺激而增加的炎症因子的表达和分泌。
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