产品
编 号：F097035
分子式：C20H23N3O4
分子量：369.41
分子式：C20H23N3O4
分子量：369.41
产品类型
规格
价格
是否有货
1mg
询价
询价
结构图
CAS No: 1256269-87-0
产品详情
生物活性：
SAK3 is a potent T-type voltage-gated Ca2+ channels (T-VGCCs) enhancer. SAK3 enhances Cav3.1 and Cav3.3 T-type Ca2+ channel currents. Acute SAK3 administration improves memory deficits in olfactory-bulbectomized mice. SAK3 inhibits amyloid β plaque formation in APP-KI mice by activating the proteasome activity.
体内研究：
Acute SAK3 (0.5 mg/kg) oral administration promotes acetylcholine (ACh) release in hippocampal CA1 via T-VGCC stimulation via enhancing T-type Ca2+ channel.Animal Model:Animal Model:Cav3.1 knockout (KO) mice
Dosage: 0.5 mg/kg
Administration:Administered p.o.
Result:Significantly increased ACh release in CA1, peaking at 20 min after oral administration.
体外研究：
SAK3 (0.01-10 nM) significantly enhances Cav3.1 or Cav3.3 currents in neuro2A cells ectopically expressing Cav3.1 or Cav3.3, respectively.
SAK3 is a potent T-type voltage-gated Ca2+ channels (T-VGCCs) enhancer. SAK3 enhances Cav3.1 and Cav3.3 T-type Ca2+ channel currents. Acute SAK3 administration improves memory deficits in olfactory-bulbectomized mice. SAK3 inhibits amyloid β plaque formation in APP-KI mice by activating the proteasome activity.
体内研究：
Acute SAK3 (0.5 mg/kg) oral administration promotes acetylcholine (ACh) release in hippocampal CA1 via T-VGCC stimulation via enhancing T-type Ca2+ channel.Animal Model:Animal Model:Cav3.1 knockout (KO) mice
Dosage: 0.5 mg/kg
Administration:Administered p.o.
Result:Significantly increased ACh release in CA1, peaking at 20 min after oral administration.
体外研究：
SAK3 (0.01-10 nM) significantly enhances Cav3.1 or Cav3.3 currents in neuro2A cells ectopically expressing Cav3.1 or Cav3.3, respectively.
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