产品
编 号：F012214
分子式：C15H18N2O
分子量：242.32
分子式：C15H18N2O
分子量：242.32
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
250
In-stock
10mg
400
In-stock
50mg
1440
In-stock
100mg
2560
In-stock
200mg
3700
In-stock
结构图
CAS No: 102518-79-6
产品详情
生物活性：
(-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease.
体内研究：
(-)-Huperzine A (0.1-0.2 mg/kg；腹腔注射；daily；for 12 days) 可减轻大鼠 icv 输注 β-淀粉样蛋白-(1-40) 引起的认知功能障碍和神经元变性。Animal Model:Male Sprague-Dawley rats (220-280 g)
Dosage:0.1 mg/kg, 0.2 mg/kg
Administration:Intraperitoneal injection, daily, for 12 days
Result:Partly reversed the down-regulation of anti-apoptotic Bcl-2 and the up-regulation of pro-apoptotic Bax and P53 proteins and reduced the apoptosis that normally followed b-amyloid injection; alleviated the cognitive dysfunction induced by b-amyloid protein-(1-40).
体外研究：
(-)- Huperzine A (1 μM；2 小时) 减轻 Aβ23-35 (20 μM) 诱导的神经元损伤。(-)- Huperzine A (100 μM) 在从大鼠海马体急性分离的 CA1 锥体神经元中的全细胞电压钳记录中可逆地抑制 NMDA 诱导的电流 (IC50=126 μM)。br/>
(-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease.
体内研究：
(-)-Huperzine A (0.1-0.2 mg/kg；腹腔注射；daily；for 12 days) 可减轻大鼠 icv 输注 β-淀粉样蛋白-(1-40) 引起的认知功能障碍和神经元变性。Animal Model:Male Sprague-Dawley rats (220-280 g)
Dosage:0.1 mg/kg, 0.2 mg/kg
Administration:Intraperitoneal injection, daily, for 12 days
Result:Partly reversed the down-regulation of anti-apoptotic Bcl-2 and the up-regulation of pro-apoptotic Bax and P53 proteins and reduced the apoptosis that normally followed b-amyloid injection; alleviated the cognitive dysfunction induced by b-amyloid protein-(1-40).
体外研究：
(-)- Huperzine A (1 μM；2 小时) 减轻 Aβ23-35 (20 μM) 诱导的神经元损伤。(-)- Huperzine A (100 μM) 在从大鼠海马体急性分离的 CA1 锥体神经元中的全细胞电压钳记录中可逆地抑制 NMDA 诱导的电流 (IC50=126 μM)。br/>
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