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编 号：F096600
分子式：C20H28N2O3
分子量：344.45
分子式：C20H28N2O3
分子量：344.45
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CAS No: 125-53-1
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生物活性：
Oxyphencyclimine is an orally active muscarinic receptor (mAChR) antagonist. Oxyphencyclimine is effective in reducing ulceration index and increasing pepsin activity in rat gastric ulcer model. Oxyphencyclimine can be used in studies of peptic ulcer disease and gastrointestinal spasm.
体内研究：
Oxyphencyclimine (10 mg/kg; p.o.; single) reduces ulceration index and increases pepsin activity in rat gastric ulcer model.Animal Model:Male or female Sprague-Dawley rats (160-170 g; Reserpine or Phenylbutazone-induced rat gastric ulcer model).
Dosage:10 mg/kg
Administration:Oral administration; single.
Result:Increased pepsin activity in Reserpine-induced gastric ulcer rat from 5.9% (1 % homogenate) and 9.0% (supernatant) to 9.7% and 18.4%, respectively.Increased pepsin activity in Phenylbutazone-induced gastric ulcer rat from 13.0% (1 % homogenate) and 26.1% (supernatant) to 21.3% and 43.6%, respectively.Decreased rate of ulcers in Reserpine and Phenylbutazone-induced rat gastric ulcer model from 93% and 100 % to 38% and 60%, respectively.
Oxyphencyclimine is an orally active muscarinic receptor (mAChR) antagonist. Oxyphencyclimine is effective in reducing ulceration index and increasing pepsin activity in rat gastric ulcer model. Oxyphencyclimine can be used in studies of peptic ulcer disease and gastrointestinal spasm.
体内研究：
Oxyphencyclimine (10 mg/kg; p.o.; single) reduces ulceration index and increases pepsin activity in rat gastric ulcer model.Animal Model:Male or female Sprague-Dawley rats (160-170 g; Reserpine or Phenylbutazone-induced rat gastric ulcer model).
Dosage:10 mg/kg
Administration:Oral administration; single.
Result:Increased pepsin activity in Reserpine-induced gastric ulcer rat from 5.9% (1 % homogenate) and 9.0% (supernatant) to 9.7% and 18.4%, respectively.Increased pepsin activity in Phenylbutazone-induced gastric ulcer rat from 13.0% (1 % homogenate) and 26.1% (supernatant) to 21.3% and 43.6%, respectively.Decreased rate of ulcers in Reserpine and Phenylbutazone-induced rat gastric ulcer model from 93% and 100 % to 38% and 60%, respectively.
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