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编 号：F096406
分子式：C32H35FN2O5
分子量：546.63
分子式：C32H35FN2O5
分子量：546.63
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CAS No: 1254730-81-8
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生物活性：
SSTR5 antagonist 2 (compound 10) is a highly potent, oral active and selective somatostatin (receptor) subtype 5 (SSTR5) antagonist and has potential for the research of treat type 2 diabetes mellitus (T2DM).
体内研究：
SSTR5 antagonist 2 (10 mg/kg, orally) increases both total and active circulating incretin hormone GLP1 levels in mice at a dose of 10 mg/kg.SSTR5 antagonist 2 increases pancreatic insulin secretion as well as total and active GLP1 release, and demonstrates synergistic effects in combination with DPP4 inhibitors.Animal Model:Rodent diabetic model without risk of hypoglycemia.
Dosage:10 mg/kg.
Administration:Orally.
Result:Increased both total and active circulating incretin hormone GLP1 levels.
SSTR5 antagonist 2 (compound 10) is a highly potent, oral active and selective somatostatin (receptor) subtype 5 (SSTR5) antagonist and has potential for the research of treat type 2 diabetes mellitus (T2DM).
体内研究：
SSTR5 antagonist 2 (10 mg/kg, orally) increases both total and active circulating incretin hormone GLP1 levels in mice at a dose of 10 mg/kg.SSTR5 antagonist 2 increases pancreatic insulin secretion as well as total and active GLP1 release, and demonstrates synergistic effects in combination with DPP4 inhibitors.Animal Model:Rodent diabetic model without risk of hypoglycemia.
Dosage:10 mg/kg.
Administration:Orally.
Result:Increased both total and active circulating incretin hormone GLP1 levels.
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