产品
编 号:F096167
分子式:C28H29Cl2N3O3
分子量:526.45
产品类型
结构图
CAS No: 1253952-02-1
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产品详情
生物活性:
Netarsudil hydrochloride (AR-13324 hydrochloride) is a Rho-associated protein kinas (ROCK) and norepinephrine transporter (NET) inhibitor. Netarsudil hydrochloride has effective in intraocular pressure (IOP) reduction.
体内研究:
Netarsudil hydrochloride (0.04%, 50 ΜL)reduces intraocular pressure (IOP) in normotensive monkey eyes.Netarsudil hydrochloride (0.04%) produces statistically significant lowering of episcleral venous pressure (EVP) in Dutch Belted rabbits.Animal Model:Adult female cynomolgus monkeys (3-5 kg)
Dosage:0.04%, 50 μL
Administration:Topically applied to eye
Result:Reduces IOP in normotensive monkey eyes.