产品
编 号：F095950
分子式：C22H16N2O
分子量：324.38
分子式：C22H16N2O
分子量：324.38
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 1253491-42-7
产品详情
生物活性：
SP-141 is a specific inhibitor of MDM2. SP-141 promotes MDM2 auto-ubiquitination and degradation. SP-141 might be used for the research of pancreatic cancer and breast cancer cells.
体内研究：
SP-141 (40 mg/kg；通过腹腔注射给药；每周 5 天，持续约三周) 抑制异种移植和原位小鼠模型中的胰腺肿瘤生长。Animal Model:Nude mice bearing Panc-1 xenograft tumors
Dosage:40 mg/kg
Administration:Administered by i.p. injection; 5 d/wk for about three weeks
Result:Significantly suppressed the growth of pancreatic xenograft tumors. On Day 18, the tumor volume in the treated group was reduced by 75% compared with that in the control group. There were no significant differences in the body weight compared with the control group.
体外研究：
SP-141 (0.01-10 μM；72 小时) 以 p53 非依赖性方式抑制人胰腺癌细胞生长，IC50 值小于 0.5 μM (0.38-0.50 μM)。IMR90细胞对SP141的敏感性远低于胰腺癌细胞，表明SP141对癌细胞具有选择性细胞毒性。SP141诱导MDM2自身泛素化和蛋白酶体降解HPAC 和 Panc-1 细胞。
SP-141 is a specific inhibitor of MDM2. SP-141 promotes MDM2 auto-ubiquitination and degradation. SP-141 might be used for the research of pancreatic cancer and breast cancer cells.
体内研究：
SP-141 (40 mg/kg；通过腹腔注射给药；每周 5 天，持续约三周) 抑制异种移植和原位小鼠模型中的胰腺肿瘤生长。Animal Model:Nude mice bearing Panc-1 xenograft tumors
Dosage:40 mg/kg
Administration:Administered by i.p. injection; 5 d/wk for about three weeks
Result:Significantly suppressed the growth of pancreatic xenograft tumors. On Day 18, the tumor volume in the treated group was reduced by 75% compared with that in the control group. There were no significant differences in the body weight compared with the control group.
体外研究：
SP-141 (0.01-10 μM；72 小时) 以 p53 非依赖性方式抑制人胰腺癌细胞生长，IC50 值小于 0.5 μM (0.38-0.50 μM)。IMR90细胞对SP141的敏感性远低于胰腺癌细胞，表明SP141对癌细胞具有选择性细胞毒性。SP141诱导MDM2自身泛素化和蛋白酶体降解HPAC 和 Panc-1 细胞。
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