产品
编 号：F095691
分子式：C18H18N2S
分子量：294.41
分子式：C18H18N2S
分子量：294.41
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
528
In-stock
10mg
800
In-stock
25mg
1760
In-stock
50mg
3040
In-stock
100mg
5520
In-stock
结构图
CAS No: 125256-00-0
产品详情
生物活性：
Fatostatin (125B11), a specific inhibitor of SREBP activation, impairs the activation of SREBP-1 and SREBP-2. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin decreases the transcription of lipogenic genes in cells. Fatostatin possesses antitumor properties, and lowers hyperglycemia in ob/ob mice.
体内研究：
Fatostatin (125B11) (30 mg/kg；150 μL；腹腔注射；每日一次，持续 28 天) 通过减少甘油三酯 (TG) 储存来减少肥胖、改善脂肪肝，并降低 ob/ob 小鼠的高血糖症。Animal Model:Four-to-five-week-old homozygous male obese (ob/ob) mice (C57BL/6J)
Dosage:30 mg/kg; 150 μL
Administration:i.p. injection; daily for 28 days
Result:Blocked increases in body weight, blood glucose, and hepatic fat accumulation in obese ob/ob mice, even under uncontrolled food intake.
体外研究：
Fatostatin (125B11) (0.1-1 μM；3 天) 抑制雄激素非依赖性前列腺癌细胞增殖 (IC50=0.1 μM)，独立于已知的 IGF1 信号通路。Fatostatin 抑制胰岛素诱导的 3T3-L1 细胞脂肪生成。 Fatostatin 直接结合 SCAP 并阻断其内质网到高尔基体的转运，IC50 为在哺乳动物细胞中为 2.5 和 10 μM。
Fatostatin (125B11), a specific inhibitor of SREBP activation, impairs the activation of SREBP-1 and SREBP-2. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin decreases the transcription of lipogenic genes in cells. Fatostatin possesses antitumor properties, and lowers hyperglycemia in ob/ob mice.
体内研究：
Fatostatin (125B11) (30 mg/kg；150 μL；腹腔注射；每日一次，持续 28 天) 通过减少甘油三酯 (TG) 储存来减少肥胖、改善脂肪肝，并降低 ob/ob 小鼠的高血糖症。Animal Model:Four-to-five-week-old homozygous male obese (ob/ob) mice (C57BL/6J)
Dosage:30 mg/kg; 150 μL
Administration:i.p. injection; daily for 28 days
Result:Blocked increases in body weight, blood glucose, and hepatic fat accumulation in obese ob/ob mice, even under uncontrolled food intake.
体外研究：
Fatostatin (125B11) (0.1-1 μM；3 天) 抑制雄激素非依赖性前列腺癌细胞增殖 (IC50=0.1 μM)，独立于已知的 IGF1 信号通路。Fatostatin 抑制胰岛素诱导的 3T3-L1 细胞脂肪生成。 Fatostatin 直接结合 SCAP 并阻断其内质网到高尔基体的转运，IC50 为在哺乳动物细胞中为 2.5 和 10 μM。
产品资料
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