产品
编 号：F094528
分子式：C23H28O6
分子量：400.46
分子式：C23H28O6
分子量：400.46
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
500mg
询价
询价
1g
询价
询价
结构图
CAS No: 125-10-0
产品详情
生物活性：
Prednisone acetate (Prednisone 21-acetate), a glucocorticoid, is an orally active Notch inhibitor. Prednisone acetate has anti-inflammatory activity and can enhance the immune response.
体内研究：
Prednisone acetate (5 mg/kg, Intragastric gavage, once a day for 4 weeks) 通过引起海马齿状回神经元病变，导致谷氨酸 (Glu) 和 NMDAR2A 减少，从而损害海马 LTP 损伤模型小鼠的空间记忆。Prednisone acetate (6 mg/kg, gavage, once a day for 15 days) 通过调控 Notch 信号通路，减轻实验性自身免疫性葡萄膜炎 (EAU) 大鼠的眼部和外周炎症反应，恢复 Th1/Th2 和 Th17/Treg 免疫稳态。Animal Model:C57BL/6 mice
Dosage:5 mg/kg
Administration:Intragastric gavage (i.g.)
Result:Significantly failed to gain weight.Decreased the population spike (%) after high-frequency stimulation.Reduced the crossing times compared with the control group.Resulted in the impairment of memory, and caused a trend of more serious impairment. Reduced the levels of Glu and gamma-aminobutyric acid (GABA) in the hippocampus. Reduced the expressions of N-methyl-D-aspartate receptors in the hippocampus.
Animal Model:Experimental autoimmune uveitis
Dosage:6 mg/kg
Administration:gavage
Result:Showed fewer manifestations in eyes from day 9 after immunization. Reduced the inflammation in EAU rats. Bound with the pocket of Notch signaling-related molecules with good affinity. Exhibited anti-inflammatory effects through inhibiting Notch signaling activation. Decreased Th1, Th17 and increased Th2, Treg frequencies in EAU.
Prednisone acetate (Prednisone 21-acetate), a glucocorticoid, is an orally active Notch inhibitor. Prednisone acetate has anti-inflammatory activity and can enhance the immune response.
体内研究：
Prednisone acetate (5 mg/kg, Intragastric gavage, once a day for 4 weeks) 通过引起海马齿状回神经元病变，导致谷氨酸 (Glu) 和 NMDAR2A 减少，从而损害海马 LTP 损伤模型小鼠的空间记忆。Prednisone acetate (6 mg/kg, gavage, once a day for 15 days) 通过调控 Notch 信号通路，减轻实验性自身免疫性葡萄膜炎 (EAU) 大鼠的眼部和外周炎症反应，恢复 Th1/Th2 和 Th17/Treg 免疫稳态。Animal Model:C57BL/6 mice
Dosage:5 mg/kg
Administration:Intragastric gavage (i.g.)
Result:Significantly failed to gain weight.Decreased the population spike (%) after high-frequency stimulation.Reduced the crossing times compared with the control group.Resulted in the impairment of memory, and caused a trend of more serious impairment. Reduced the levels of Glu and gamma-aminobutyric acid (GABA) in the hippocampus. Reduced the expressions of N-methyl-D-aspartate receptors in the hippocampus.
Animal Model:Experimental autoimmune uveitis
Dosage:6 mg/kg
Administration:gavage
Result:Showed fewer manifestations in eyes from day 9 after immunization. Reduced the inflammation in EAU rats. Bound with the pocket of Notch signaling-related molecules with good affinity. Exhibited anti-inflammatory effects through inhibiting Notch signaling activation. Decreased Th1, Th17 and increased Th2, Treg frequencies in EAU.
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