产品
编 号：F012069
分子式：C10H4Br5NO
分子量：553.66
分子式：C10H4Br5NO
分子量：553.66
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CAS No: 10245-81-5
产品详情
生物活性：
Pentabromopseudilin (PBrP) is a marine antibiotic isolated from the marine bacteria Pseudomonas bromoutilis and Alteromonas luteoviolaceus. PBrP exhibits antimicrobial, anti-tumour and phytotoxic activities. PBrP is a reversible and allosteric inhibitor of myosin Va (MyoVa). PBrP also is a potent inhibitor of transforming growth factor-β (TGF-β) activity. PBrP can be used for the research of fibrotic diseases and cancer.
体外研究：
Pentabromopseudilin (PBrP) (0.01-1?μM, 6 h) 可防止 TGF-β 诱导的 Smad 蛋白磷酸化和核转位。PBrP (0.5 μM, 6 h) 抑制 TGF-β 刺激的转录反应。PBrP (0-1 μM, 6 h) 抑制 A549 细胞中 TGF-β 诱导的 EMT。PBrP (0.2 μM, 20 h) 抑制 TGF-β 诱导的细胞迁移。PBrP (0.01-1?μM, 6 h) 通过增强 TβRII 的降解来阻断 TGF-β 信号传导。PBrP (0.5μM, 0, 1, 3 h) 通过细胞膜穴样内陷增强 TβRII 的降解来阻断 TGF-β 信号传导。
Pentabromopseudilin (PBrP) is a marine antibiotic isolated from the marine bacteria Pseudomonas bromoutilis and Alteromonas luteoviolaceus. PBrP exhibits antimicrobial, anti-tumour and phytotoxic activities. PBrP is a reversible and allosteric inhibitor of myosin Va (MyoVa). PBrP also is a potent inhibitor of transforming growth factor-β (TGF-β) activity. PBrP can be used for the research of fibrotic diseases and cancer.
体外研究：
Pentabromopseudilin (PBrP) (0.01-1?μM, 6 h) 可防止 TGF-β 诱导的 Smad 蛋白磷酸化和核转位。PBrP (0.5 μM, 6 h) 抑制 TGF-β 刺激的转录反应。PBrP (0-1 μM, 6 h) 抑制 A549 细胞中 TGF-β 诱导的 EMT。PBrP (0.2 μM, 20 h) 抑制 TGF-β 诱导的细胞迁移。PBrP (0.01-1?μM, 6 h) 通过增强 TβRII 的降解来阻断 TGF-β 信号传导。PBrP (0.5μM, 0, 1, 3 h) 通过细胞膜穴样内陷增强 TβRII 的降解来阻断 TGF-β 信号传导。
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