产品
编 号:F086964
分子式:C9H16O4
分子量:188.22
产品类型
结构图
CAS No: 123-99-9
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产品详情
生物活性:
Azelaic acid is a nine-carbon dicarboxylic acid. Azelaic acid has antimicrobial activity against Propionibacterium acnes and Staphylococcus epidermidis through inhibition of microbial cellular prorein synthesis. Azelaic acid has hypopigmentation action resulting from its ability to scavenge free radicals.
体内研究:
Azelaic acid (15% 凝胶,涂抹,每日两次) 在 15% 凝胶中对中度丘疹-脓疱有效。Animal Model:Human with rosacea for 12 weeks
Dosage:15% gel
Administration:Smear
Result:Showed excellent improvent in 78% of the patients with Azelaic acid.
体外研究:
Azelaic acid (0.5 M, 48 h-7 D) 具有抑菌作用。Azelaic acid (5 M, 24 h) 可降低细胞内活性氧 (ROS) 水平,增加抗氧化能力。Azelaic acid (1-100 nM,24 小时) 以剂量依赖性方式抑制 B16、HMB2 和 SK23 细胞的存活能力。