产品
编 号：F085756
分子式：C23H23NO2
分子量：345.43
分子式：C23H23NO2
分子量：345.43
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 1236109-67-3
产品详情
生物活性：
TUG-469 is a selective free fatty acid receptor 1 (FFA1/GPR40) agonist with an EC50 value of 19 nM. TUG-469 is >200-fold selective for FFA1 over FFA4. TUG-469 significantly improves glucose tolerance in pre-diabetic mice. TUG-469 can be used for the research of diabetes.
体内研究：
TUG-469 (5 mg/kg; i.p.; 60 and 90 min after glucose administration) affects blood glucose level.Animal Model:Male NZO mice with glucose administration
Dosage:5 mg/kg
Administration:Intraperitoneal injection; 5 mg/kg; 60 and 90 min after glucose administration
Result:Reduced the blood glucose level.
体外研究：
TUG-469 (0-10 μM) shows efficacy to hFFA1 with a pEC50 value of 7.73.TUG-469 (10 μM) increases the insulin secretion under 10 mM glucose stimulation.TUG-469 (0-100 μM) is >200-fold selective for FFA1 over FFA4 with EC50 values of 19 nM and 4.4 μM for FFA1 and FFA4, respectively.TUG-469 (5 μM; 30 min) significantly increases insulin secretion of INS-1 cells with the presence of high glucose concentration (16.7 mM).
TUG-469 is a selective free fatty acid receptor 1 (FFA1/GPR40) agonist with an EC50 value of 19 nM. TUG-469 is >200-fold selective for FFA1 over FFA4. TUG-469 significantly improves glucose tolerance in pre-diabetic mice. TUG-469 can be used for the research of diabetes.
体内研究：
TUG-469 (5 mg/kg; i.p.; 60 and 90 min after glucose administration) affects blood glucose level.Animal Model:Male NZO mice with glucose administration
Dosage:5 mg/kg
Administration:Intraperitoneal injection; 5 mg/kg; 60 and 90 min after glucose administration
Result:Reduced the blood glucose level.
体外研究：
TUG-469 (0-10 μM) shows efficacy to hFFA1 with a pEC50 value of 7.73.TUG-469 (10 μM) increases the insulin secretion under 10 mM glucose stimulation.TUG-469 (0-100 μM) is >200-fold selective for FFA1 over FFA4 with EC50 values of 19 nM and 4.4 μM for FFA1 and FFA4, respectively.TUG-469 (5 μM; 30 min) significantly increases insulin secretion of INS-1 cells with the presence of high glucose concentration (16.7 mM).
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