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编 号:F763058
分子式:C21H27NO3
分子量:341.44
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生物活性:
(Rac)-BMS-816336 (Compound 6n) is a racemate of BMS-816336. (Rac)-BMS-816336 is a potent inhibitor of human and mouse 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme with IC50s of 10 nM and 68 nM, respectively. (Rac)-BMS-816336 has good metabolic stability.

体内研究:
(Rac)-BMS-816336 (compound 6n) has good metabolic stability, and the remaining rates in human, mouse and rats of 88%,82% and 72%, respectively.
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