产品
编 号：F763033
分子式：C68H104N10O12S
分子量：1285.68
分子式：C68H104N10O12S
分子量：1285.68
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CAS No: 2916441-36-4
产品详情
生物活性：
HIV-1 protease-IN-7 (compound 16) is an orally active HIV-1 protease inhibitor (IC50=3.52 nM, EC50=37 nM).
体内研究：
HIV-1 protease-IN-7 (2.57 mg/kg; p.o.; single) exhibits good plasma total clearance and oral bioavailability.Animal Model:Male Sprague-Dawley rats (8-week-old).
Dosage:2.57 mg/kg (2 μM/kg)
Administration:Oral administration; single.
Result:1.19Pharmacokinetic Parameters of HIV-1 protease-IN-7 in male Sprague-Dawley rats.metabolic stability rat/human (%)CLtot (mL/min/kg)Vdss (L/kg)t1/2 (h)F (%)serum fu(%)
PO (2.57 mg/kg)63/238.21.93.93.30.1
HIV-1 protease-IN-7 (compound 16) is an orally active HIV-1 protease inhibitor (IC50=3.52 nM, EC50=37 nM).
体内研究：
HIV-1 protease-IN-7 (2.57 mg/kg; p.o.; single) exhibits good plasma total clearance and oral bioavailability.Animal Model:Male Sprague-Dawley rats (8-week-old).
Dosage:2.57 mg/kg (2 μM/kg)
Administration:Oral administration; single.
Result:1.19Pharmacokinetic Parameters of HIV-1 protease-IN-7 in male Sprague-Dawley rats.metabolic stability rat/human (%)CLtot (mL/min/kg)Vdss (L/kg)t1/2 (h)F (%)serum fu(%)
PO (2.57 mg/kg)63/238.21.93.93.30.1
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