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编 号:F763028
分子式:C21H24ClN3O3
分子量:401.89
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生物活性:
MAO A/HDAC-IN-1 is a dual?inhibitor?of monoamine oxidase A (MAO A) and HDAC. MAO A/HDAC-IN-1 can be used for glioma research. MAO A/HDAC-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

体内研究:
MAO A/HDAC-IN-1 (compound 15) reduces tumor size, reduced MAO A activity in brain and tumor tissues, and prolonged the survival.

体外研究:
MAO A/HDAC-IN-1 (compound 15) increases histone H3 and α-tubulin acetylation and induce cell death via nonapoptotic mechanisms.
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