产品
编 号：F763014
分子式：C33H33N3O4
分子量：535.63
分子式：C33H33N3O4
分子量：535.63
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规格
价格
是否有货
结构图
CAS No: 3031349-98-8
产品详情
生物活性：
PDE1-IN-4 (compound 2g) is a potent and selective PDE1 (phosphodiesterase-1) inhibitor, with IC50 values of 10, 145, and 354 nM for PDE1C, PDE1A, and PDE1B, respectively. PDE1-IN-4 inhibits myofibroblast differentiation of human lung fibroblasts induced by TGF-β1. PDE1-IN-4 shows anti-fibrosis effects through the regulation of cAMP (3′,5′-cyclic adenosine monophosphate) and cGMP (3′,5′-cyclic guanosine monophosphate). PDE1-IN-4 can be used for idiopathic pulmonary fibrosis (IPF) research.
体外研究：
PDE1-IN-4 (compound 2g) shows weak inhibition against the hERG channel with an IC50 above 40 μM, indicating that it will not cause cardiotoxicity.
PDE1-IN-4 (compound 2g) is a potent and selective PDE1 (phosphodiesterase-1) inhibitor, with IC50 values of 10, 145, and 354 nM for PDE1C, PDE1A, and PDE1B, respectively. PDE1-IN-4 inhibits myofibroblast differentiation of human lung fibroblasts induced by TGF-β1. PDE1-IN-4 shows anti-fibrosis effects through the regulation of cAMP (3′,5′-cyclic adenosine monophosphate) and cGMP (3′,5′-cyclic guanosine monophosphate). PDE1-IN-4 can be used for idiopathic pulmonary fibrosis (IPF) research.
体外研究：
PDE1-IN-4 (compound 2g) shows weak inhibition against the hERG channel with an IC50 above 40 μM, indicating that it will not cause cardiotoxicity.
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