产品
编 号：F763004
分子式：C31H29ClN4O6
分子量：589.04
分子式：C31H29ClN4O6
分子量：589.04
产品类型
规格
价格
是否有货
结构图
CAS No: 3031406-27-3
产品详情
生物活性：
MLKL-IN-3 (compound 66) is a potent MLKL (Mixed lineage kinase domain-like protein) inhibitor. MLKL-IN-3 inhibits necroptosis in HT-29 cells and acts downstream of MLKL phosphorylation, with EC50 of 31 nM. MLKL-IN-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
体内研究：
MLKL-IN-3 (compound 66) shows T1/2 over 48 h and more than 150-fold lower reaction rates with glutathione (GSH), which potentially decreased their off-target effects and cell toxicity.
体外研究：
MLKL-IN-3 (compound 66) (1 μM, 24 h) inhibits the translocation of MLKL to cell membranes in HT-29 cells.MLKL-IN-3 does not affect the phosphorylation status of RIPK1 and MLKL.
MLKL-IN-3 (compound 66) is a potent MLKL (Mixed lineage kinase domain-like protein) inhibitor. MLKL-IN-3 inhibits necroptosis in HT-29 cells and acts downstream of MLKL phosphorylation, with EC50 of 31 nM. MLKL-IN-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
体内研究：
MLKL-IN-3 (compound 66) shows T1/2 over 48 h and more than 150-fold lower reaction rates with glutathione (GSH), which potentially decreased their off-target effects and cell toxicity.
体外研究：
MLKL-IN-3 (compound 66) (1 μM, 24 h) inhibits the translocation of MLKL to cell membranes in HT-29 cells.MLKL-IN-3 does not affect the phosphorylation status of RIPK1 and MLKL.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备