产品
编 号：F762975
分子式：C26H23N3O6S4
分子量：601.74
分子式：C26H23N3O6S4
分子量：601.74
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CAS No: 3031666-31-3
产品详情
生物活性：
hCAIX/XII-IN-6 is an orally active carbonic anhydrase (CA) inhibitor. hCAIX/XII-IN-6 inhibits human CA isoforms hCA I, II, IV, IX, and XII with Ki values of 6697 nM, 2950 nM, 4093 nM, 4.1 nM and 7.7 nM, respectively. hCAIX/XII-IN-6 can be used for the research of rheumatoid arthritis (RA).
体内研究：
hCAIX/XII-IN-6 (oral; 1, 10, 30 mg/kg; single) completely reverts the pain state 45 min after administration and enhances antihyperalgesic effect in vivo.Animal Model:adjuvant-induced arthritis rat model
Dosage:1, 10, 30 mg/kg
Administration:oral, single
Result:Evoked an antihypersensitivity effect in a dose-dependent manner.Reduced spontaneous pain in a dose-dependent mannerwith a peak of efficacy between 30 and 45 min.
体外研究：
hCAIX/XII-IN-6 has inhibition activitr for human CA isoforms hCA I, II,IV, IX, and XII with Ki values of 6697 nM, 2950 nM, 4093 nM, 4.1 nM and 7.7 nM, respectively.hCAIX/XII-IN-6 (150 μM) exhibits a weaker H2S releas.
hCAIX/XII-IN-6 is an orally active carbonic anhydrase (CA) inhibitor. hCAIX/XII-IN-6 inhibits human CA isoforms hCA I, II, IV, IX, and XII with Ki values of 6697 nM, 2950 nM, 4093 nM, 4.1 nM and 7.7 nM, respectively. hCAIX/XII-IN-6 can be used for the research of rheumatoid arthritis (RA).
体内研究：
hCAIX/XII-IN-6 (oral; 1, 10, 30 mg/kg; single) completely reverts the pain state 45 min after administration and enhances antihyperalgesic effect in vivo.Animal Model:adjuvant-induced arthritis rat model
Dosage:1, 10, 30 mg/kg
Administration:oral, single
Result:Evoked an antihypersensitivity effect in a dose-dependent manner.Reduced spontaneous pain in a dose-dependent mannerwith a peak of efficacy between 30 and 45 min.
体外研究：
hCAIX/XII-IN-6 has inhibition activitr for human CA isoforms hCA I, II,IV, IX, and XII with Ki values of 6697 nM, 2950 nM, 4093 nM, 4.1 nM and 7.7 nM, respectively.hCAIX/XII-IN-6 (150 μM) exhibits a weaker H2S releas.
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